Abstract
Objectives: Due a growing range of therapeutic options, early diagnosis of pulmonary arterial hypertension may change survival of patients. This study performed to evaluate effect of concomitant pulmonary arterial hypertension on outcome of new cases of pulmonary tuberculosis.
Methods: A cross sectional study of 777 new cases of pulmonary tuberculosis were recruited in National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran. Pulmonary arterial hypertension was defined as systolic pulmonary arterial pressure >30 mmHg estimated by resting transthoracic echocardiography. We assessed the relationship between pulmonary arterial hypertension on admission and survival during six months treatment of tuberculosis.
Results: Of 777 new cases of pulmonary tuberculosis, 74 (9.5%) had systolic pulmonary arterial pressure >30 mmHg. Ten of them (13.5%) died during treatment period in comparison to 5% among cases without pulmonary arterial hypertension (P=0.007). Logistic regression analysis confirmed this association.
Conclusion: A significant association was found between mortality and presence of pulmonary arterial hypertension among new cases of pulmonary tuberculosis. Therapeutic intervention may change outcome of these patients.
- © 2011 ERS