Abstract
We have previously demonstrated the association between bronchiolitis from Rhinovirus (RV) and recurrent wheezing after one yr of follow-up (Eur Respir J 2010; 36 (54) P2707). Our objective was to identify wheezing recurrence and related risk factors in infants with bronchiolitis from Respiratory Syncytial Virus (RSV), RV, Bocavirus (hBoV), Influenza A and B, Parainfluenza 1-3, Metapneumovirus, Adenovirus and Coronavirus detected from nasal washes with RT-PCR. 208 infants (mean age ± SD 2.4±2.1, range 0.07-11 months, 89 males) hospitalized with bronchiolitis were evaluated for recurrent wheezing (RW) during 3 yrs of follow-up. Demographic and clinical data were obtained from parents with a structured questionnaire and patient's medical files. Of they 208 infants, 152 (73%) answered to the phone call. 104 viruses were identified from 92 infants: RSV in 68 (73.9%), RV in 15 (16.3%), hBoV in 17 (18.5%), RSV+hBoV in 10 (10.9%), other viruses in 4 (4.34%). 34.9% of the infants with bronchiolitis had RW at the 3rd yr of follow-up. The related risk factors for RW were blood eosinophils counts > 400 cells/mm3 (OR 9.26; CI 95% 1.09,79.0), breast feeding more than 2 months (OR 2.43; CI 1.20,4.89) and bronchiolitis from RV (OR 3.17; CI 1.03,9.79). At the 3rd yr of follow-up, 66.7% of the infants with bronchiolitis from RV have RW comparing to 57.1% of the infants with bronchiolitis from hBoV, 39.7% of the infants with bronchiolitis from RSV, 30% of the infants with bronchiolitis from RSV+hBoV and 25% of the infants with bronchiolitis from other viruses. In conclusion infants with RW at the 3rd yr of follow-up after acute bronchiolitis seem to be those with atopic predisposition and a specific viral infection.
- © 2011 ERS