History (nonspecific) | Throat tightness/closure, globus sensation, chest tightness, audible wheezing (inspiratory versus expiratory), stridor triggers: irritants, exercise trigger poor response or aggravation by inhaled medications (MDI>nebulised) |
Lung function tests | |
Symptom-free period | Normal findings? |
| MIF50<MEF50? |
Acute dyspnoea (may be provoked by methacholine/ histamine challenge, exercise, irritant challenge) | Inspiratory or expiratory flow limitationTruncated flow-volume loopsDeviation of the resistance loop (inspiratory/expiratory)?Laryngoscopy (endospirometry) |
ENT examination (laryngoscopy) | Post-nasal drip? |
| LPR? |
Evaluation of reflux GER disease/LPR | pH probe |