Drug type | Specific drug | Licensing arrangements |
PERT
| Pancreatin, for example | |
| Creon 10,000TM (Solvay, Southampton, UK) | Pancreatic insufficiency in children of all ages |
| Creon MicroTM (Solvay, Southampton, UK) | Pancreatic insufficiency in children of all ages |
| Nutrizym 10TM (Merck Serono, Feltham, UK) | Children aged over 2 yrs |
| PancrexTM (Paines and Byrne, Staines, UK) | Children aged over 2 yrs (capsules in infants) |
| High-strength preparations | Not licensed for children under 15 yrs with CF |
Oral calorie supplements
| Different licensing arrangements (ACBS) | Children aged over 3 yrs |
Drugs to reduce gastric acid
| Omeprazole | Capsules and tablets not licensed in children except for severe ulcerating reflux oesophagitis (injection not licensed in children aged under 12 yrs) |
| Lansoprazole | Not licensed for children |
| Ranitidine | Oral not licensed in children aged under 3 yrs (injections not licensed in children aged under 6 months) |
| Cimetidine | Not licensed in children aged under 1 yr |
Treatment for DIOS
| Gastrografin | Licensed for uncomplicated meconium ileus (not specifically licensed for DIOS, but is licensed for “infants and young children”) |
| N-Acetylcysteine | Not licensed for use in children with CF |
Sodium bicarbonate
| | Not licensed |
Laxatives
| Lactulose | Licensed for children |
| Bisacodyl | Not licensed for children aged under 10 yrs |
| Docusate | Not licensed for children aged under 12 yrs |
| MovicolTM (Norgine, Harefield, UK) | Licensed for children aged 2 yrs and older |
Fat soluble vitamins
| Vitamin E suspension | Licensed for children with CF (all age groups) |
| Multivitamin drops | Licensed for children of all ages |
Motility agents
| Domperidone | Not licensed for children |
Taurine
| | Not licensed for children |