| NRAD | fBOS |
Inflammation (BAL) | Neutrophilic airway inflammation | No airway inflammation |
Clinically | Coarse crackles and increased sputum production | No coarse crackles, minimal sputum |
Time of onset | Early onset after transplantation | Late onset after transplantation |
Progression | Slow progression, several years | Rapid progression, 6 months |
Histology | Initially inflammatory, ends in pure fibrosis | Pure fibrosis |
Radiology | Bronchiectasis, airway wall thickening andmucus plugging | Air trapping andconsolidation |
Azithromycin | Reversible (effective) | Irreversible (ineffective) |