Decade | Drugs currently available | Drugs in development | Therapeutics that have failed |
1960s | Short-acting β2-agonists | | Neuropeptide antagonists |
1980s | Long-acting β2 agonists | Type IV PDE inhibitors (mostly targeted for COPD) | PAF antagonists |
1960s | Inhaled and oral corticosteroids | Anti-TNF | Thromboxane inhibitors |
1990s | Leukotriene receptor antagonists | | Bradykinin antagonists |
1970s | (Cytotoxics and immunosuppressants)# | | Anti-IL-5 mAb |
1930s | Theophylline | | hr IL-12 |
1950s | Anti-cholinergics | | hr IFN-γ |
2000s | Anti-human IgE mAb | | hr IL-10 |
| | | Soluble IL-4 receptor |
| | | IL-4 double mutein |
| | | Allergen-specific IL |
| | | VLA-4 antagonists |
| | | P-selectin mAb |
| | | Antihistamines |
| | | Mast cell “stabilisers” |