| Asthma | Control |
ICS- | ICS+ |
Subjects n | 22 | 23 | 14 |
Age yrs | 48±21 | 56±13 | 26±7¶ |
Sex (male/female) | 7/15 | 9/14 | 9/5 |
Lifetime smoking nonsmoker/ex-smoker | 20/2 | 20/3 | 14/0 |
Disease duration yrs | 5.9±7.0 | 10.9±9.8+ | |
FEV1 % pred | 87±23 | 90±18 | 94±9 |
FEV1/FVC % | 72±9 | 72±11 | 88±7§ |
FEF25–75% % pred | 60±32 | 55±24 | 100±20§ |
BMI kg·m−2 | 22±3 | 23±4 | 21±2 |
Serum hs-CRP mg·L−1 | 1.3±1.5 | 0.9±1.0 | 0.2±0.3ƒ |
Cell counts in induced sputum# | | | |
Macrophages cells×105·g−1 | 2.3±3.2 | 4.1±4.9 | 8.1±5.5 |
Neutrophils cells×105·g−1 | 9.8±15.8 | 19.7±34.2 | 3.2±2.2 |
Eosinophils cells×105·g−1 | 3.5±9.2 | 7.0±11.9 | 0.0±0.1## |
Lymphocytes cells×105·g−1 | 0.2±0.4 | 0.4±0.1 | 0.3±0.3 |