TB vaccine type | Definition | Stage of development | References |
Subunit vaccines | | | |
72f | Selected antigens identified from human response | Phase I trial | 23 |
85B-ESAT6 | Recombinant major antigens | Ready for phase I trial | 19 |
| | BCG boosting strategy | |
DNA vaccines | | | |
85B | Plasmid DNA of Ag85B | Pre-clinical testing | 18 |
Viral vector | | | |
MVA-85A | Recombinant modified vaccinia virus Ankara Ag85A | Phase I trial | 25, 37 |
| | BCG boosting strategy | |
Live vaccines | | | |
rBCG30 | Recombinant BCG: over-expression of Ag85B | Phase I trial | 26, 27 |
BCG:RD1 | Recombinant BCG: RD-1 of M. tuberculosis introduced | Pre-clinical studies | 28 |
rBCG-hly | Recombinant BCG: listeriolysin of Listeria monocytogenes introduced | Pre-clinical testing | 29 |
M. tuberculosis phoP mutant | Attenuated M. tuberculosis clinical isolated by phoP deletion | Pre-clinical testing | 32 |
M. tuberculosis auxotrophic mutant | Attenuated M. tuberculosis H37Rv by lysA and panCD deletion | Pre-clinical testing | 34 |