1. Headache | 0 None |
| 1 Mild |
| 2 Moderate |
| 3 Severe, incapacitating |
2. Gastrointestinal symptoms | 0 None |
| 1 Poor appetite or nausea |
| 2 Moderate nausea or vomiting |
| 3 Severe nausea or vomiting, incapacitating |
3. Fatigue and/or weakness | 0 None |
| 1 Mild |
| 2 Moderate |
| 3 Severe, incapacitating |
4. Dizziness/lightheadedness | None |
| Mild |
| Moderate |
| Severe, incapacitating |
5. Difficulty sleeping | 0 Slept as usual |
| 1 Did not sleep as well as usual |
| 2 Woke up many times, poor night sleep |
| 3 Could not sleep at all |
Clinical assessment by investigator: | |
6. Change in mental status | 0 None |
| 1 Lethargy/lassitude |
| 2 Disoriented/confused |
| 3 Stupor/semiconsciousness |
| 4 Coma |
7. Ataxia (heel-to-toe walking) | 0 None |
| 1 Manoeuvres to maintain balance |
| 2 Steps off line |
| 3 Falls down |
| 4 Can't stand |
8. Peripheral oedema | 0 None |
| 1 Peripheral oedema at one location |
| 2 Peripheral oedema at two or more locations |