| Controls | COPD |
General characteristics | |
M:F | 14:2 | 12:3 |
Age yrs | 64±3 | 67±9 |
BMI kg·m−2 | 26.3±3.3 | 23.9±4.0 |
FFM kg | 58.2±9.0 | 48.8±6.9** |
FFMI kg·m−2 | 19.6±2.2 | 17.2±1.7** |
FEV1 % pred | 109±17.2 | 42±13.9*** |
Pa,O2 kPa | 11.8±1.6 | 9.9±1.2*** |
DL,CO % pred | 123±23 | 63±24*** |
RV % pred | 114±15 | 167±32*** |
ITGV % pred | 108±17 | 144±22*** |
Muscle function | | |
Leg power at 20 cm·s−1 W | 265±62 | 203±88* |
Leg power at 60 cm·s−1 W | 561±154 | 363±145** |
Handgrip strength kg | 43±8 | 31±8*** |
Muscle biopsy | | |
Proportion of type‐I fibres % | 43.4±12.6 | 19.4±14.0*** |
Proportion of type-IIA fibres % | 29.4±12.1 | 34.8±11.9 |
Proportion of type-IIX fibres % | 27.2±12.3 | 45.8±18.9*** |
CSA of type-IIX fibres µm2 | 4248±1300 | 2566±1137** |