Abstract
Bronchiectasis can have different causes. Etiology impact on clinical and functional aspects is little known.
Objectives: Identify causes of bronchiectasis non cystic fibrosis(BNFC) and investigate if there are differences concerning clinical, functional and of quality of life(QoL) among groups.
Methods: Descriptive and cross-sectional study conducted in a Brazilian University hospital. Patients (N=109, mean age 53 yrs, 60% women) with tomographic diagnosis of bronchiectasis had medical files reviewed and were interviewed to identify personal and familial antecedents; they also performed spirometry and answered the Saint George QoL questionnaire(SGRQ).
Results: mean values: FVC:64%; FEV1:53%; BMI:26kg/m2, SGRQ score:45%. Cardiovascular diseases, dyslipidemia and diabetes were present in 36%, 5% and 16%, respectively. Apart from 26% of the cases with undetermined cause, other causes were post-infectious(23%), ciliary dyskinesia(CD)(16%), COPD(15%), and immunodeficiency(7%). Of all antecedents surveyed, only pneumonia before 10 years-old was associated with diagnosis, being more frequent in CD and idiopathic groups(p=0.02). There was an age difference: COPD patients were older(65 yrs) and CD ones, younger (43 yrs)(p=0.005). COPD subjects had worse pulmonary function (p=0.014) and more dyslipidemia(p=0.056). Differing from other groups(p<0.001), tuberculosis(TB) was found in 48% of postinfectious cases. There was no difference among groups regarding SGRQ, other comorbidities, MRC nor tobacco load.
Conclusion: Causes were identified in 74% of the cases; COPD patients are older and have worse lung function. TB was very frequent in posinfectious BNFC.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4354.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019