Abstract
Introduction: Fat tissue produced inflammatory cytokines which have an impact on systemic diseases such as sarcoidosis(S). Treatment with corticosteroids(CS) can worsen metabolic disoders and patients’ life quality
Aim: to assess the role of obesity in clinical aspect of S
Methods: 142 patients with S were observed at pulmonology depratment Tareev Clinic. BMI was calculated before treatment was start. Patients were divided into 2groups:gr.1-with obesity(BMI≥30kg/m2)(n=84),gr.2-without obesity(n=58). Control group consisted of 35 patients with chonic bronchitis and obesity
Results: There was prevelance of middle aged women with obesity among patients with S. Male patients were charecterised by younger age and lower BMI. Obesity in patients with S was significantly(p<0,05, 95% confidence interval not includes 1) associated with female gender, older onset age, slow development of sarcoiodosis(OR 2,36) with inflammetory changes in blood analysis (9.5), higher rate of skin(3.2), bone(4,0) and liver(3,1) involvement. Patients in gr.2 had significantly (p<0,05) higher rate(8,2), stage and level of arterial hypertenison, higer cardio-vascular risk, rate of diabetus mellitus(16,7), liver steatosis(6,1), dyslipidemia(2,7), chronic kidney disease(3,5); higher level of proteinuria, creatinine, uric acid, glucose, glutamyltransferase, alkaline phosphatase, alanintranspeptidase, lactatdehydrogenase, tryglycerides and IgA. There were no significant differences in metabolic disoders(MD) and comorbities(C) between gr.2 and control group.
Conclusion: Obesity in patients with S leads to the same MD, C as in general population and have influence to the course of the disease. It is important to consider MD, C before CS-tretment will start, to save life quality
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1951.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019