ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (216)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barnes, P.J.
Right arrow Articles by Pauwels, R.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barnes, P.J.
Right arrow Articles by Pauwels, R.A.
Eur Respir J 2003; 22:672-688
Copyright ©ERS Journals Ltd 2003

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

P.J. Barnes1, S.D. Shapiro2 and R.A. Pauwels3

1 National Heart and Lung Institute, ImperialCollege, London, UK, 2 Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, 3 Dept of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium

CORRESPONDENCE: P.J. Barnes, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London, SW3 6LY, UK. Fax: 44 2073515675. E-mail: p.j.barnes@imperial.ac.uk

Keywords: chemokine, cytokine, emphysema, macrophage, oxidative stress, protease

Received: April 10, 2003
Accepted June 12, 2003

The meeting "COPD: the important questions" held in Malta in November 2002 was sponsored by AstraZeneca.

Abstract

Chronic obstructive pulmonary disease is a leading cause of death and disability, but has only recently been extensively explored from a cellular and molecular perspective.

There is a chronic inflammation that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This is characterised by increased numbers of alveolar macrophages, neutrophils and cytotoxic T-lymphocytes, and the release of multiple inflammatory mediators (lipids, chemokines, cytokines, growth factors). A high level of oxidative stress may amplify this inflammation. There is also increased elastolysis and evidence for involvement of several elastolytic enzymes, including serine proteases, cathepsins and matrix metalloproteinases.

The inflammation and proteolysis in chronic obstructive pulmonary disease is an amplification of the normal inflammatory response to cigarette smoke. This inflammation, in marked contrast to asthma, appears to be resistant to corticosteroids, prompting a search for novel anti-inflammatory therapies that may prevent the relentless progression of the disease.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
G. T. Motz, B. L. Eppert, G. Sun, S. C. Wesselkamper, M. J. Linke, R. Deka, and M. T. Borchers
Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema
J. Immunol., December 1, 2008; 181(11): 8036 - 8043.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E J Hothersall, R Chaudhuri, C McSharry, I Donnelly, J Lafferty, A D McMahon, C J Weir, J Meiklejohn, N Sattar, I McInnes, et al.
Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
Thorax, December 1, 2008; 63(12): 1070 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Igarashi, E. Heureux, K. S. Doctor, P. Talwar, S. Gramatikova, K. Gramatikoff, Y. Zhang, M. Blinov, S. S. Ibragimova, S. Boyd, et al.
PMAP: databases for analyzing proteolytic events and pathways
Nucleic Acids Res., October 8, 2008; (2008) gkn683v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Almolki, A. Guenegou, S. Golda, L. Boyer, M. Benallaoua, N. Amara, R. Bachoual, C. Martin, F. Rannou, S. Lanone, et al.
Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans
Am. J. Pathol., October 1, 2008; 173(4): 981 - 992.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Takeda, P. He, I. Tachibana, B. Zhou, K. Miyado, H. Kaneko, M. Suzuki, S. Minami, T. Iwasaki, S. Goya, et al.
Double Deficiency of Tetraspanins CD9 and CD81 Alters Cell Motility and Protease Production of Macrophages and Causes Chronic Obstructive Pulmonary Disease-like Phenotype in Mice
J. Biol. Chem., September 19, 2008; 283(38): 26089 - 26097.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. I. Rennard and J. Vestbo
The Many "Small COPDs": COPD Should Be an Orphan Disease
Chest, September 1, 2008; 134(3): 623 - 627.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. H. van Houwelingen, N. M. Weathington, V. Verweij, J. E. Blalock, F. P. Nijkamp, and G. Folkerts
Induction of lung emphysema is prevented by L-arginine-threonine-arginine
FASEB J, September 1, 2008; 22(9): 3403 - 3408.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Yang, M. A. Nugent, and M. P. Panchenko
EGF antagonizes TGF-{beta}-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L143 - L151.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. F. Chung and I. M. Adcock
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. R. Celli
Update on the Management of COPD
Chest, June 1, 2008; 133(6): 1451 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. J. Moghaddam, C. G. Clement, M. M. De la Garza, X. Zou, E. L. Travis, H. W. J. Young, C. M. Evans, M. J. Tuvim, and B. F. Dickey
Haemophilus influenzae Lysate Induces Aspects of the Chronic Obstructive Pulmonary Disease Phenotype
Am. J. Respir. Cell Mol. Biol., June 1, 2008; 38(6): 629 - 638.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Z. Ammous, N. R. Hackett, M. W. Butler, T. Raman, I. Dolgalev, T. P. O'Connor, B.-G. Harvey, and R. G. Crystal
Variability in Small Airway Epithelial Gene Expression Among Normal Smokers
Chest, June 1, 2008; 133(6): 1344 - 1353.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Ji, C. M. Lee, L. W. Gonzales, Y. Yang, M. O. Aksoy, P. Wang, E. Brailoiu, N. Dun, M. T. Hurford, and S. G. Kelsen
Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A
Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1187 - L1196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. G. Kelsen, X. Duan, R. Ji, O. Perez, C. Liu, and S. Merali
Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung: A Proteomic Approach
Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 541 - 550.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Mahabir, Q. Wei, S. L. Barrera, Y. Q. Dong, C. J. Etzel, M. R. Spitz, and M. R. Forman
Dietary magnesium and DNA repair capacity as risk factors for lung cancer
Carcinogenesis, May 1, 2008; 29(5): 949 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Rajendrasozhan, S.-R. Yang, V. L. Kinnula, and I. Rahman
SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 861 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Slevogt, L. Maqami, K. Vardarowa, W. Beermann, A. C. Hocke, J. Eitel, B. Schmeck, A. Weimann, B. Opitz, S. Hippenstiel, et al.
Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms
Eur. Respir. J., April 1, 2008; 31(4): 725 - 735.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-W. Park, H. P. Kim, S.-J. Lee, X. Wang, Y. Wang, E. Ifedigbo, S. C. Watkins, M. Ohba, S. W. Ryter, Y. M. Vyas, et al.
Protein Kinase C{alpha} and {zeta} Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis
J. Immunol., April 1, 2008; 180(7): 4668 - 4678.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Churg, M. Cosio, and J. L. Wright
Mechanisms of cigarette smoke-induced COPD: insights from animal models
Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L612 - L631.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Fuschillo, A. De Felice, and G. Balzano
Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms
Eur. Respir. J., February 1, 2008; 31(2): 396 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Mori, T. Nose, K. Ishitani, S. Kasagi, S. Souma, T. Akiyoshi, Y. Kodama, T. Mori, M. Kondo, S. Sasaki, et al.
Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L196 - L204.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. C. Sieck, T. A. White, M. A. Thompson, C. M. Pabelick, M. E. Wylam, and Y. S. Prakash
Regulation of store-operated Ca2+ entry by CD38 in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L378 - L385.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Doz, N. Noulin, E. Boichot, I. Guenon, L. Fick, M. Le Bert, V. Lagente, B. Ryffel, B. Schnyder, V. F. J. Quesniaux, et al.
Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent
J. Immunol., January 15, 2008; 180(2): 1169 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. D. Sin, S. B.-Z. Cohen, A. Day, H. Coxson, and P. D. Pare
Understanding the Biological Differences in Susceptibility to Chronic Obstructive Pulmonary Disease between Men and Women
Proceedings of the ATS, December 1, 2007; 4(8): 671 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. van der Toorn, M. P. Smit-de Vries, D.-J. Slebos, H. G. de Bruin, N. Abello, A. J. M. van Oosterhout, R. Bischoff, and H. F. Kauffman
Cigarette smoke irreversibly modifies glutathione in airway epithelial cells
Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1156 - L1162.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Agusti
Systemic Effects of Chronic Obstructive Pulmonary Disease: What We Know and What We Don't Know (but Should)
Proceedings of the ATS, October 1, 2007; 4(7): 522 - 525.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
N. Roche
Where current pharmacological therapies fall short in COPD: symptom control is not enough
Eur. Respir. Rev., September 1, 2007; 16(105): 98 - 104.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. Churg, X. Wang, R. D. Wang, S. C. Meixner, E. L. G. Pryzdial, and J. L. Wright
{alpha}1-Antitrypsin Suppresses TNF-{alpha} and MMP-12 Production by Cigarette Smoke-Stimulated Macrophages
Am. J. Respir. Cell Mol. Biol., August 1, 2007; 37(2): 144 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Ben-Zaken Cohen, P. D. Pare, S. F. P. Man, and D. D. Sin
The Growing Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer in Women: Examining Sex Differences in Cigarette Smoke Metabolism
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 113 - 120.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
V. Pinto-Plata, J. Toso, K. Lee, D. Park, J. Bilello, H. Mullerova, M. M De Souza, R. Vessey, and B. Celli
Profiling serum biomarkers in patients with COPD: associations with clinical parameters
Thorax, July 1, 2007; 62(7): 595 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. A. Stringer, M. Tobias, H. C. O'Neill, and C. C. Franklin
Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1572 - L1579.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. K. Demedts, K. R. Bracke, G. Van Pottelberge, D. Testelmans, G. M. Verleden, F. E. Vermassen, G. F. Joos, and G. G. Brusselle
Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 998 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. van der Toorn, D.-J. Slebos, H. G. de Bruin, H. G. Leuvenink, S. J. L. Bakker, R. O. B. Gans, G. H. Koeter, A. J. M. van Oosterhout, and H. F. Kauffman
Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1211 - L1218.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Ito, G. Caramori, and I. M. Adcock
Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D.-J. Slebos, S. W. Ryter, M. van der Toorn, F. Liu, F. Guo, C. J. Baty, J. M. Karlsson, S. C. Watkins, H. P. Kim, X. Wang, et al.
Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke-Induced Cell Death
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Churg, H. Tai, T. Coulthard, R. Wang, and J. L. Wright
Cigarette Smoke Drives Small Airway Remodeling by Induction of Growth Factors in the Airway Wall
Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1327 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
H. Fehrenbach
Animal models of pulmonary emphysema: a stereologist's perspective
Eur. Respir. Rev., December 1, 2006; 15(101): 136 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Rytila, M. Plataki, F. Bucchieri, M. Uddin, G. Nong, V. L. Kinnula, and R. Djukanovic
Airway neutrophilia in COPD is not associated with increased neutrophil survival
Eur. Respir. J., December 1, 2006; 28(6): 1163 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G M Turino
Emphysema in COPD: consequences and causes.
Thorax, December 1, 2006; 61(12): 1031 - 1036.
[Full Text] [PDF]

Home page
 ThoraxHome page
P Boschetto, S Quintavalle, E Zeni, S Leprotti, A Potena, L Ballerin, A Papi, G Palladini, M Luisetti, L Annovazzi, et al.
Association between markers of emphysema and more severe chronic obstructive pulmonary disease
Thorax, December 1, 2006; 61(12): 1037 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. Gebel, B. Gerstmayer, P. Kuhl, J. Borlak, K. Meurrens, and T. Muller
The Kinetics of Transcriptomic Changes Induced by Cigarette Smoke in Rat Lungs Reveals a Specific Program of Defense, Inflammation, and Circadian Clock Gene Expression
Toxicol. Sci., October 1, 2006; 93(2): 422 - 431.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. R. Bracke, A. I. D'hulst, T. Maes, K. B. Moerloose, I. K. Demedts, S. Lebecque, G. F. Joos, and G. G. Brusselle
Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice
J. Immunol., October 1, 2006; 177(7): 4350 - 4359.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. D. Sin and S. F. P. Man
Pharmacotherapy for Mortality Reduction in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, September 1, 2006; 3(7): 624 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Zandvoort, D. S. Postma, M. R. Jonker, J. A. Noordhoek, J. T. W. M. Vos, Y. M. van der Geld, and W. Timens
Altered expression of the Smad signalling pathway: implications for COPD pathogenesis
Eur. Respir. J., September 1, 2006; 28(3): 533 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. I. Zervou, E. G. Tzortzaki, D. Makris, M. Gaga, E. Zervas, E. Economidou, M. Tsoumakidou, N. Tzanakis, J. Milic-Emili, and N. M. Siafakas
Differences in microsatellite DNA level between asthma and chronic obstructive pulmonary disease
Eur. Respir. J., September 1, 2006; 28(3): 472 - 478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Against the dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases.
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 240 - 243.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. K. Baginski, K. Dabbagh, C. Satjawatcharaphong, and D. C. Swinney
Cigarette Smoke Synergistically Enhances Respiratory Mucin Induction by Proinflammatory Stimuli
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 165 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Shifren and R. P. Mecham
The stumbling block in lung repair of emphysema: elastic fiber assembly.
Proceedings of the ATS, July 1, 2006; 3(5): 428 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. I. D'hulst, K. R. Bracke, T. Maes, J. L. De Bleecker, R. A. Pauwels, G. F. Joos, and G. G. Brusselle
Role of tumour necrosis factor-{alpha} receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
Eur. Respir. J., July 1, 2006; 28(1): 102 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Zandvoort, Y. M. van der Geld, M. R. Jonker, J. A. Noordhoek, J. T. W. M. Vos, J. Wesseling, H. F. Kauffman, W. Timens, and D. S. Postma
High ICAM-1 gene expression in pulmonary fibroblasts of COPD patients: a reflection of an enhanced immunological function
Eur. Respir. J., July 1, 2006; 28(1): 113 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes, B. Chowdhury, S. A. Kharitonov, H. Magnussen, C. P. Page, D. Postma, and M. Saetta
Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 6 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S.-R. Yang, A. S. Chida, M. R. Bauter, N. Shafiq, K. Seweryniak, S. B. Maggirwar, I. Kilty, and I. Rahman
Cigarette smoke induces proinflammatory cytokine release by activation of NF-{kappa}B and posttranslational modifications of histone deacetylase in macrophages
Am J Physiol Lung Cell Mol Physiol, July 1, 2006; 291(1): L46 - L57.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
O. Leclerc, V. Lagente, J-M. Planquois, C. Berthelier, M. Artola, T. Eichholtz, C. P. Bertrand, and F. Schmidlin
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice
Eur. Respir. J., June 1, 2006; 27(6): 1102 - 1109.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M A Dentener, R Louis, R H E Cloots, M Henket, and E F M Wouters
Differences in local versus systemic TNF{alpha} production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNF{alpha} release
Thorax, June 1, 2006; 61(6): 478 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. P. de Torres, E. Cordoba-Lanus, C. Lopez-Aguilar, M. Muros de Fuentes, A. Montejo de Garcini, A. Aguirre-Jaime, B. R. Celli, and C. Casanova
C-reactive protein levels and clinically important predictive outcomes in stable COPD patients
Eur. Respir. J., May 1, 2006; 27(5): 902 - 907.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. O. Aksoy, Y. Yang, R. Ji, P. J. Reddy, S. Shahabuddin, J. Litvin, T. J. Rogers, and S. G. Kelsen
CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L909 - L918.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Marwick, C. S. Stevenson, J. Giddings, W. MacNee, K. Butler, I. Rahman, and P. A. Kirkham
Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L897 - L908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Vlahos, S. Bozinovski, J. E. Jones, J. Powell, J. Gras, A. Lilja, M. J. Hansen, R. C. Gualano, L. Irving, and G. P. Anderson
Differential protease, innate immunity, and NF-{kappa}B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L931 - L945.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Slevogt, B. Schmeck, C. Jonatat, J. Zahlten, W. Beermann, V. van Laak, B. Opitz, S. Dietel, P. D. N'Guessan, S. Hippenstiel, et al.
Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-{kappa}B activation and histone deacetylase activity reduction
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L818 - L826.
[Abstract] [Full Text] [PDF]