|
 |
|
|||||||
|
|||||||||
Eur Respir J 2006, doi:10.1183/09031936.06.00130405
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL ARTICLE |
Measurement of quality of life in pulmonary hypertension and its significance
1 Dept of Internal Medicine, University Hospital, Zurich, Switzerland
* To whom correspondence should be addressed. E-mail: klinspr{at}usz.unizh.ch.
 |
Abstract |
|---|
Until recently, assessment of patients with pulmonary hypertension has mainly relied on functional and haemodynamic parameters. Health-related quality of life (HRQOL), however, has become increasingly important in defining overall health status.
We investigated the performance and clinical relevance of the Minnesota Living with Heart Failure (MLHF) questionnaire by prospectively studying 48 patient with either pulmonary arterial hypertension (n=26) or chronic thromboembolic pulmonary hypertension (n=22). The MLHF scores were correlated to various clinical and haemodynamic parameters. Prognostic outcome was evaluated by calculating the time to an adverse clinical event defined as death, lung transplantation or pulmonary endarterectomy.
Test-re-test reliability and internal consistency reliability of this HRQOL tool were high. The MLHF score and its physical subscore correlated moderately to well with functional and haemodynamic parameters except the pulmonary artery pressures. Both scores significantly improved during vasodilator therapy. This figure was surpassed only by the NYHA/WHO functional class. A multivariate analysis of all variables revealed that the MLHF score was the sole factor predicting subsequent outcome (p=0.015).
The MLHF questionnaire is a highly reproducible and consistent, as well as a moderately valid and responsive tool in assessing HRQOL in pulmonary hypertension. Moreover, it is a significant predictor of outcome in these patients.
Keywords: Prognosis, pulmonary hypertension, quality of life, vasodilator therapy
This article has been cited by other articles:
|
|
 |
|
  M. Rubenfire, G. Lippo, B. D. Bodini, F. Blasi, L. Allegra, and E. Bossone Evaluating Health-Related Quality of Life, Work Ability, and Disability in Pulmonary Arterial Hypertension: An Unmet Need Chest, August 1, 2009; 136(2): 597 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Ghofrani, M. W. Wilkins, and S. Rich Uncertainties in the Diagnosis and Treatment of Pulmonary Arterial Hypertension Circulation, September 9, 2008; 118(11): 1195 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, D. B. Taichman, and R. L. Doyle Health-related Quality of Life and Patient-reported Outcomes in Pulmonary Arterial Hypertension Proceedings of the ATS, July 15, 2008; 5(5): 623 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ulrich, M. Fischler, R. Speich, and K. E. Bloch Sleep-Related Breathing Disorders in Patients With Pulmonary Hypertension Chest, June 1, 2008; 133(6): 1375 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 National Pulmonary Hypertension Centres of the UK Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland Heart, March 1, 2008; 94(Suppl_1): i1 - i41. [Full Text] [PDF]
|
|
|
|
 |
|
 National Pulmonary Hypertension Centres of the UK Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland Thorax, March 1, 2008; 63(Suppl_2): ii1 - ii41. [Full Text] [PDF]
|
|
|
|
|
|
J. Pepke-Zaba, C. Gilbert, L. Collings, and M. C. J. Brown Sildenafil Improves Health-Related Quality of Life in Patients With Pulmonary Arterial Hypertension Chest, January 1, 2008; 133(1): 183 - 189. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |