GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone

¹ Instituto Nacional de Salud Publica de México
² Hospital Infantil "Federico Gómez", México
³ Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, NC, USA

^* To whom correspondence should be addressed. E-mail: iromieu{at}correo.insp.mx.

	Abstract

Acute exposure to ozone has been related to a wide spectrum of health effects in susceptible individuals. Genetic factors may influence inter-individual variation in ozone response. We investigated the relation between common polymorphisms in two genes involved in response to oxidative stress, glutathione S-transferases M1 (GSTM1) and P1 (GSTP1), and both respiratory symptoms and lung function in response to ozone among childhood asthmatics.

We studied 151 asthmatic children, participants in a randomized controlled trial of antioxidant vitamin supplementation in Mexico City. Children were genotyped using PCR methods and followed from October 1998-April 2000.

Increases in reported difficulty breathing were associated with ozone exposure in children with GSTM1 null (8%, 95%CI 1% to 15%, per 20 ppb increase in 1-hour maximum daily average over 7 days) or GSTP1 Val/Val genotypes (14%, 95%CI 5% to 25%). In children with both GSTM1 null and GSTP1 Val/Val genotypes, the increase in difficulty breathing associated with 20 ppb increase in ozone exposure was even greater (21%, 95%CI 5% to 39%). GSTP1 genotypes were not significantly associated with ozone-related lung function changes.

Asthmatic children with GSTM1 null and GSTP1 Val/Val genotypes appear more susceptible to developing respiratory symptoms related to ozone exposure.

This article has been cited by other articles:

				J. S. Brown Acute Effects of Exposure to Ozone in Humans: How Low Can Levels Be and Still Produce Effects? Am. J. Respir. Crit. Care Med., August 1, 2009; 180(3): 200 - 201. [Full Text] [PDF]

				I A Yang, K M Fong, P V Zimmerman, S T Holgate, and J W Holloway Genetic susceptibility to the respiratory effects of air pollution Postgrad. Med. J., August 1, 2009; 85(1006): 428 - 436. [Abstract] [Full Text] [PDF]

				J. A. Voynow, B. M. Fischer, S. Zheng, E. N. Potts, A. R. Grover, A. K. Jaiswal, A. J. Ghio, and W. M. Foster NAD(P)H Quinone Oxidoreductase 1 Is Essential for Ozone-Induced Oxidative Stress in Mice and Humans Am. J. Respir. Cell Mol. Biol., July 1, 2009; 41(1): 107 - 113. [Abstract] [Full Text] [PDF]

				A. Peters, S. Greven, I. M. Heid, F. Baldari, S. Breitner, T. Bellander, C. Chrysohoou, T. Illig, B. Jacquemin, W. Koenig, et al. Fibrinogen Genes Modify the Fibrinogen Response to Ambient Particulate Matter Am. J. Respir. Crit. Care Med., March 15, 2009; 179(6): 484 - 491. [Abstract] [Full Text] [PDF]

				E Rage, V Siroux, N Kunzli, I Pin, F Kauffmann, and on behalf of the Epidemiological Study on the Gene Air pollution and asthma severity in adults Occup. Environ. Med., March 1, 2009; 66(3): 182 - 188. [Abstract] [Full Text] [PDF]

				F. D. Gilliland Outdoor Air Pollution, Genetic Susceptibility, and Asthma Management: Opportunities for Intervention to Reduce the Burden of Asthma Pediatrics, March 1, 2009; 123(Supplement_3): S168 - S173. [Abstract] [Full Text] [PDF]

				B. Kapitein, M. O. Hoekstra, E. H. J. Nijhuis, D. J. Hijnen, H. G. M. Arets, J. L. L. Kimpen, and E. F. Knol Gene expression in CD4+ T-cells reflects heterogeneity in infant wheezing phenotypes Eur. Respir. J., November 1, 2008; 32(5): 1203 - 1212. [Abstract] [Full Text] [PDF]

				S E Alexeeff, A A Litonjua, R O Wright, A Baccarelli, H Suh, D Sparrow, P S Vokonas, and J Schwartz Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging study Occup. Environ. Med., November 1, 2008; 65(11): 736 - 742. [Abstract] [Full Text] [PDF]

				I A Yang, K M Fong, P V Zimmerman, S T Holgate, and J W Holloway Genetic susceptibility to the respiratory effects of air pollution Thorax, June 1, 2008; 63(6): 555 - 563. [Abstract] [Full Text] [PDF]

				M. Pichavant, S. Goya, E. H. Meyer, R. A. Johnston, H. Y. Kim, P. Matangkasombut, M. Zhu, Y. Iwakura, P. B. Savage, R. H. DeKruyff, et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17 J. Exp. Med., February 18, 2008; 205(2): 385 - 393. [Abstract] [Full Text] [PDF]

				C. Chen, M. Arjomandi, I. B. Tager, N. Holland, and J. R. Balmes Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes Eur. Respir. J., October 1, 2007; 30(4): 677 - 683. [Abstract] [Full Text] [PDF]

				S. J. London Gene-Air Pollution Interactions in Asthma Proceedings of the ATS, July 1, 2007; 4(3): 217 - 220. [Abstract] [Full Text] [PDF]