C-reactive protein levels and clinically important predictive outcomes in stable COPD patients

¹ Respiratory Research Unit, Hospital Ntra Sra de Candelaria, Tenerife, Spain
² Biochemical Analysis Dept, Hospital Ntra Sra de Candelaria, Tenerife, Spain
³ Pulmonary and Critical Care Division. St. Elizabeth's Medical Center, Boston, USA

^* To whom correspondence should be addressed. E-mail: jupa65{at}hotmail.com.

	Abstract

Determine the relationship between CRP levels and factors known to predict outcome in stable COPD patients.

We studied 130 stable COPD patients with: spirometry, lung volumes, PaO₂, dyspnoea, 6 minute walk distance, body mass index, free fat mass index, BODE index, health related quality of life, smoking status, the presence of cardiovascular risk factors or disease, corticosteroids use and number of exacerbations in the previous year. CRP levels were measured in these patients and in 65 control and using univariate and multivariate analysis evaluated any possible association with the predictors of outcomes.

CRP levels were higher in COPD patients than in controls (4.1 vs. 1.8 mg·L^-1 respectively, p<0.001). Correlation was found with the following variables: FEV₁ (-0.23, p=0.008), FEV₁% (-0.20, p=0.03), FVC (-0.24, p=0.006), FVC% (-0.24,p=0.006), GOLD stage (0.17, p=0.04), BODE (0.17, p=0.05), IC/TLC (-0.20, p=0.04), PaO₂ (-0.40, p<0.001) and 6MWD (-0.30, p=0.001). Using multivariate analysis, PaO₂ and 6MWD manifested the strongest negative association with CRP levels.

CRP levels in stable COPD patients are best correlated with PaO₂ and 6MWD. This information should be considered when CRP levels are measured in stable COPD patients.

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