|
 |
|
|||||||
|
|||||||||
Eur Respir J 2006, doi:10.1183/09031936.06.00107805
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL ARTICLE |
Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up
1 Sleep Laboratory, Dept of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg; and Sleep Medicine Unit, Dept of Neurorehabilitation, Skaraborg Hospital, Skoevde, Sweden
2 Sleep Laboratory, Dept of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg
* To whom correspondence should be addressed. E-mail: yuksel.peker{at}lungall.gu.se.
 |
Abstract |
|---|
We have previously reported an increased incidence of cardiovascular disease in middle-aged men during a follow-up period of 7 years. In the current study, we addressed the incidence of coronary artery disease (CAD) in a larger sample (308 snorers; 245 men, 63 women; mean age 49.0±9.9 yrs in 1991) without any heart disease at baseline. Data was collected via the Swedish Hospital Discharge Register, National Cause of Death Registry, clinical charts and questionnaires. During 7 years, CAD was observed in 17 of 105 cases (16.2%) with OSA (overnight oxygen desaturations
30) compared with in 11 of 203 (5.4 %) snorers without OSA (p=0.003). OSA diagnosis at baseline was associated with an increased relative risk (RR) of 4.6 (95% confidence interval [CI] 1.8-11.6) for development of CAD (p=0.001) in a multivariate model. In the OSA group, CAD was confirmed in 16 of 65 incompletely treated cases (24.6%) compared with in 1 of 26 (3.9%) efficiently treated subjects (p=0.022). Efficient treatment of OSA reduced this risk (RR 0.3, 95% CI 0.1-0.8; p=0.020). We conclude that middle-aged sleep apnoeics are at high risk of developing CAD if they are not treated efficiently, which should be considered in the cardiovascular prevention models.
This article has been cited by other articles:
|
|
 |
|
  N. Sjosten, J. Vahtera, P. Salo, T. Oksanen, T. Saaresranta, M. Virtanen, J. Pentti, and M. Kivimaki Increased Risk of Lost Workdays Prior to the Diagnosis of Sleep Apnea Chest, July 1, 2009; 136(1): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Bonsignore and J. Eckel Metabolic aspects of obstructive sleep apnoea syndrome Eur. Respir. Rev., June 1, 2009; 18(112): 113 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Solak, F. Fidan, U. Dundar, A. Turel, A. Aycicek, V. Kavuncu, and M. Unlu The prevalence of obstructive sleep apnoea syndrome in ankylosing spondylitis patients Rheumatology, April 1, 2009; 48(4): 433 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Khayat, W. T. Abraham, B. Patt, M. Roy, K. Hua, and D. Jarjoura Cardiac Effects of Continuous and Bilevel Positive Airway Pressure for Patients With Heart Failure and Obstructive Sleep Apnea: A Pilot Study Chest, December 1, 2008; 134(6): 1162 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J F Guest, M T Helter, A Morga, and J R Stradling Cost-effectiveness of using continuous positive airway pressure in the treatment of severe obstructive sleep apnoea/hypopnoea syndrome in the UK Thorax, October 1, 2008; 63(10): 860 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Valham, T. Mooe, T. Rabben, H. Stenlund, U. Wiklund, and K. A. Franklin Increased Risk of Stroke in Patients With Coronary Artery Disease and Sleep Apnea: A 10-Year Follow-Up Circulation, August 26, 2008; 118(9): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Phillips, B. Yee, Q. Yang, A. T. Villaneuva, J. Hedner, N. Berend, and R. Grunstein Effects of Continuous Positive Airway Pressure Treatment and Withdrawal in Patients With Obstructive Sleep Apnea on Arterial Stiffness and Central BP Chest, July 1, 2008; 134(1): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Punjabi The Epidemiology of Adult Obstructive Sleep Apnea Proceedings of the ATS, February 15, 2008; 5(2): 136 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. McNicholas Diagnosis of Obstructive Sleep Apnea in Adults Proceedings of the ATS, February 15, 2008; 5(2): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Amit Benjamin and K E Lewis Sleep-disordered breathing and cardiovascular disease Postgrad. Med. J., January 1, 2008; 84(987): 15 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Punjabi, B. A. Beamer, A. Jain, M. E. Spencer, and N. Fedarko Elevated Levels of Neopterin in Sleep-Disordered Breathing Chest, October 1, 2007; 132(4): 1124 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schulz, A. Blau, J. Borgel, H. W. Duchna, I. Fietze, I. Koper, R. Prenzel, S. Schadlich, J. Schmitt, S. Tasci, et al. Sleep apnoea in heart failure Eur. Respir. J., June 1, 2007; 29(6): 1201 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. El Solh, M. E. Akinnusi, F. H. Baddoura, and C. R. Mankowski Endothelial Cell Apoptosis in Obstructive Sleep Apnea: A Link to Endothelial Dysfunction Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1186 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. McNicholas, M. R. Bonsignore, and the Management Committee of EU COST ACTION B26 Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities Eur. Respir. J., January 1, 2007; 29(1): 156 - 178. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |