Anti-inflammatory cytokines in cystic fibrosis lung disease

¹ Lung Research Group, Children's Hospital of Ludwig Maximilians University, Munich, Germany
² Dept of paediatrics, University of Essen, Essen
³ Dept of paediatric Pneumology and Allergology, Children's Hospital, University of Cologne, Cologne
⁴ Dept of paediatric Pneumology and Immunology, Charité, Humboldt-University, Berlin, Germany

^* To whom correspondence should be addressed. E-mail: matthias.griese{at}med.uni-muenchen.de.

	Abstract

Lung inflammation plays a pivotal role in the pathogenesis of airway disease in cystic fibrosis (CF). An imbalance between pro- and anti-inflammatory mediators has been observed and a deficiency in the anti-inflammatory response has been proposed, but this concept remains controversial.

In this study we assessed the concentrations of two anti-inflammatory mediators, lipoxin A (LxA₄) and Clara cell protein 10 (CC-10) in bronchoalveolar lavage fluid of CF patients with a wide range of endobronchial inflammation and disease controls with neutrophilic inflammation unrelated to CF.

No differences were observed in LxA₄ BALF concentrations between CF patients and controls with a similar degree of neutrophilic airway inflammation. Concentrations were also similar in CF patients with mild versus more severe airway inflammation. In contrast, CC-10 concentrations were lower in CF patients, but this decrease was limited to patients with more intense airway inflammation.

These data do not support the concept of a primary defect in anti-inflammatory mediators in CF lung disease. Although CC-10 concentrations were found to be reduced, these alterations appear to be secondary to neutrophilic airway inflammation rather than due to a primary deficiency.

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