THE Trp64Arg polymorphism of the beta (3) adrenergic receptor is associated with increased body mass index in patients with sleep apnoea

¹ Serveis de Anàlisis Cliniques i Pneumologia, Hospital Universitari Son Dureta Palma de Mallorca
² Hospital Universitario Arnau de Vilanova, Lleida
³ Fundació Caubet-CIMERA, Illes Balears, Mallorca
⁴ Hospital Virgen del Rocio, Sevilla
⁵ Hospital Txagorritxu, Vitoria-Gasteiz, all in Spain
⁶ Serveis de Anàlisis Cliniques i Pneumologia, Hospital Universitari Son Dureta Palma de Mallorca; and Fundació Caubet-CIMERA, Illes Balears, Mallorca

^* To whom correspondence should be addressed. E-mail: abarcelo{at}hsd.es.

	Abstract

Obesity is an important risk factor for obstructive sleep apnoea syndrome (OSAS), insulin resistance and cardiovascular disease. The Trp64Arg polymorphism (Arg variant) of the ₃-adrenergic receptor (ADRB3) has been associated with obesity. In this study we evaluated the prevalence of the Trp64Arg ADRB3 polymorphism in a large group of patients with OSAS and its association with body mass index (BMI), insulin resistance and hypertension.

We determined the ADBR3 genotypes in 387 patients with OSAS and 137 healthy subjects recruited from three tertiary Spanish hospitals.

The distribution of the ADRB3 genotypes was similar in OSAS and controls and, in a multivariate model, the risk of OSAS was not associated with the presence of the Arg variant in the ADRB3 gene. However, in those patients with OSAS who carried this genetic variant BMI was higher than in those with the Trp64Trp one (p<0.01). Further, a linear trend for higher BMI was found in those with the Arg variant (56%, 75% and 100% in Trp/Trp, Trp/Arg and Arg/Arg, respectively, p for trend=0.001). Insulin resistance, blood pressure values and serum levels of lipids and glucose were not associated with the presence of the Arg variant in the ADRB3 gene.

The presence of the Trp64Arg allele in the ADBR3 gene does not increase the risk for OSAS but it is associated with the development of obesity in those patients who suffer OSAS.

This article has been cited by other articles:

				R. L. Riha, T. Gislasson, and K. Diefenbach The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome Eur. Respir. J., March 1, 2009; 33(3): 646 - 655. [Abstract] [Full Text] [PDF]

				S. Kapoor Trp64Arg polymorphisms of the Beta3-adrenergic receptor gene and systemic disorders of metabolism: a close association Ann Clin Biochem, January 1, 2009; 46(1): 82 - 83. [Full Text] [PDF]