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Published online before print January 7, 2009
Eur Respir J 2009, doi:10.1183/09031936.00140408
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ORIGINAL ARTICLE

Converting venous acid-base and oxygen status to arterial in patients with lung disease

S.E. Rees 1*, A. Hansen 2, M. Toftegaard 3, J. Pedersen 4, S.R. Kristiensen 4, H. Harving 2

1 Center for Model Based Medical Decision Support Systems, Department of Health Science and Technology, Aalborg University, Denmark
2 Dept of Respiratory Diseases, Aalborg Hospital, Aarhus University Hospital, Denmark
3 Center for Model Based Medical Decision Support Systems, Department of Health Science and Technology, Aalborg University, Denmark; and Dept of Anaesthesia and Intensive Care, Aalborg Hospital, Aarhus University Hospital, Denmark
4 Dept of Clinical Biochemistry, Centre of Cardiovascular research, Aalborg Hospital, Aarhus University Hospital, Denmark

* To whom correspondence should be addressed. E-mail: sr{at}hst.aau.dk.


  Abstract

To evaluate a method for calculating arterial values of pH, PCO2 and PO2 from peripheral venous values.

40 patients were studied. Arterial and peripheral venous blood were sampled at a department of respiratory diseases. Arterial values were calculated from venous and measured and calculated values of arterial pH, PCO2 and PO2 compared.

Measured and calculated values of pH and PCO2 correlated well (pH r2=0.95, PCO2 r2=0.98) with the difference between them having a very small bias and standard deviation (pH -0.001±0.013, PCO2 -0.09±0.28 kPa) within those considered acceptable for laboratory equipment and clinical practice. All but 4 patients had SpO2 ≤96%, and for these measured and calculated PO2 correlated well (r2=0.86) with a difference such that the bias and standard deviation suggested that calculated PO2 may be clinically useful (PO2 0.11±0.53 kPa).

This paper evaluates a method for calculating arterial pH, PCO2 and PO2 from venous blood. It has been shown that arterial pH and PCO2 can be calculated precisely, and that PO2 can be calculated with reasonable precision in the vast majority of patients. This method might be useful in reducing the need for painful arterial punctures.

Keywords:  Acid-base chemistry, blood gas analysis, oxygen saturation




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G. S. Zavorsky
Accuracy of venous blood oxygen pressure depends on arterial blood oxygen pressure
Eur. Respir. J., November 1, 2009; 34(5): 1207 - 1208.
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 Eur Respir JHome page
S. E. Rees
From the author:
Eur. Respir. J., November 1, 2009; 34(5): 1208 - 1208.
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