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Published online before print September 5, 2007
Eur Respir J 2007, doi:10.1183/09031936.00083507
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ORIGINAL ARTICLE

Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America

A.M.B. Menezes 1*, P.C. Hallal 1, R. Perez-Padilla 2, J.R.B. Jardim 3, A. Muiño 4, M.V. Lopez 4, G. Valdivia 5, M. Montes de Oca 6, C. Talamo 6, J. Pertuze 5, C.G. Victora 1, for the PLATINO Team*

1 Universidade Federal de Pelotas, Brazil
2 Instituto Nacional de Enfermedades Respiratorias, Mexico
3 Universidade Federal de São Paulo, Brazil
4 Universidad de la República, Montevideo, Uruguay
5 Pontifícia Universidad Católica de Chile, Chile
6 Universidad Central de Venezuela, Venezuela

* To whom correspondence should be addressed. E-mail: anamene{at}terra.com.br.


  Abstract

To evaluate the association between history of tuberculosis and airflow obstruction.

Population-based, multi-centre study including 5600 subjects aged 40 years or older living in five Latin American metropolitan areas – Sao Paulo (Brazil), Montevideo (Uruguay), Mexico City (Mexico), Santiago (Chile), and Caracas (Venezuela). Subjects performed pre and post-bronchodilator spirometry and were asked whether they had ever been diagnosed with tuberculosis by a physician.

The overall prevalence of airflow obstruction (FEV1/FVC <0.7 post-bronchodilator) was 30.7% among those with a history of tuberculosis, compared to 13.9% among those without a history. Males with a medical history of tuberculosis were 4.1 times more likely to present airflow obstruction than those without such a diagnosis (P=0.000). This remained unchanged after adjustment for confounding by age, sex, schooling, ethnicity, smoking, exposure to dust and smoke, respiratory morbidity in childhood and current morbidity. Among women, the unadjusted and adjusted odds ratios were 2.3 (P=0.001) and 1.7 (P=0.08), respectively.

History of tuberculosis is associated with airflow obstruction in Latin American middle-aged and older adults.

Keywords:  Chronic bronchitis, COPD, developing countries, smoking, spirometry, tuberculosis




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