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Published online before print January 23, 2008
Eur Respir J 2008, doi:10.1183/09031936.00063207
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ORIGINAL ARTICLE

Reference equations for CO and NO lung transfer, membrane conductance and capillary lung volume in a healthy European population

B. Aguilaniu 1, J. Maitre 1, S. Glenet 2, A. Gegout-Petit 3, H. Guenard 2

1 HYLAB Laboratoire Physiologie Clinique et Exercice, Grenoble, France
2 Laboratoire de physiologie Université Bordeaux 2, Explorations fonctionnelles respiratoires CHU Bordeaux France
3 Institut de Mathématique de Bordeaux. Université Bordeaux 2


  Abstract

NO and CO lung transfer (TL) were measured in 303 people whose ages ranged between 18 and 94 years. Measurements were similarly taken in two distant cities using the single breath technique. Capillary lung volume (Vc) and membrane conductance (Dm CO) were derived. The transfer of both gases appeared to depend on age, height, gender, and localization. The rate of decrease in both transfers increased after the age of 59. TLNO/VA and TLCO/VA were age-dependent only. The means for TLNO/TLCO and Dm/Vc were 4.75 and 0.82 (min mmHg)-1 (confidence intervals 4.1 to 5.4 and 0.63 to 1.04) respectively and these parameters were independent of any covariate. Vc and Dm CO calculations depend on the choice of the coefficients included in the Roughton Forster equation. Values of 1.97 for DmNO/DmCO ratio and 1.71 (min mmHg) for 1/{theta}CO are recommended. The scatter of transfer reference values in the literature, including this study, is wide. The present results suggest that differences might be due to the populations themselves and not only the methods.

Keywords:  Ageing, alveolo-capillary membrane, capillary lung volume, carbon monoxide, diffusion, nitric oxide, pollution




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