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Published online before print January 24, 2007
Eur Respir J 2007, doi:10.1183/09031936.00061806
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ORIGINAL ARTICLE

Serological test and chest computed tomography findings in patients with MAC lung disease

S. Kitada 1*, Y. Nishiuchi 2, T. Hiraga 1, N. Naka 1, H. Hashimoto 1, K. Yoshimura 1, K. Miki 1, M. Miki 1, M. Motone 1, T. Fujikawa 1, K. Kobayashi 3, I. Yano 4, R. Maekura 1

1 Dept of Internal Medicine, NHO National Toneyama Hospital, Osaka, Japan
2 Toneyama Institute for Tuberculosis Research, Osaka, Japan
3 Dept of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
4 Japan BCG Laboratory, Tokyo Japan

* To whom correspondence should be addressed. E-mail: kitadas{at}toneyama.hosp.go.jp.


  Abstract

We previously reported the usefulness of a serodiagnostic test to detect serum glycopeptidolipid (GPL) core antibody in diagnosing Mycobacterium avium complex (MAC) lung disease in immunocompetent patients. The aim of the present study was to investigate correlations between the levels of antibody against GPL core and chest computed tomography (CCT) findings in patients with MAC lung disease.

Forty-seven patients with MAC-positive culture from their sputum and who had radiographic abnormality were investigated. 33 patients met the American Thoracic society criteria for MAC disease, 14 did not. All patients underwent both CCT examination and the serodiagnostic test for MAC at the same time.

Small nodular shadows were seen in all patients and bronchiectasis shadows were seen in 39 of them on CCT (83.0%). There was a significant positive correlation between the extent of the disease and the level of GPL core IgA antibody (r=0.514, p<0.001). The levels of GPL core IgA antibody were significantly elevated in patients who had nodular shadow (10-30 mm) compared to patients who had small nodular shadow (<10 mm)

These results document that the levels of IgA antibody against GPL core do correlate with the CCT findings of MAC lung disease.

Keywords:  Early stage, enzyme immunoassay, glycopeptidolipid, mycobacteria others than tuberculosis




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Copyright © 2007 by the European Respiratory Society.