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Published online before print October 18, 2006
Eur Respir J 2006, doi:10.1183/09031936.00059706
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ORIGINAL ARTICLE

Impact of CPAP on asthmatic patients with sleep apnoea

C. Lafond 1*, F. Sériès 2, C. Lemière 1

1 Hôpital du Sacré-Coeur, Montréal, QC, Canada (chantal.lafond@umontreal.ca, catherine.lemiere@umontreal.ca)
2 Unité de recherche en pneumologie, Centre de recherche de l’Hôpital Laval, Institut Universitaire de cardiologie et de pneumologie de l’Université Laval, Université Laval, Quebec City, Canada. (frederic.series@med.ulaval.ca)

* To whom correspondence should be addressed. E-mail: chantal.lafond{at}umontreal.ca.


  Abstract

The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea has scarcely been studied.

We performed a prospective study comparing the changes in airway responsiveness and quality of life, in stable asthmatic sleep apnoea patients, before and 6 weeks after their nocturnal CPAP treatment.

Twenty subjects (11 males, 9 women) completed the study. With the nocturnal CPAP treatment, the apnoea-hypopnoea index (AHI) dropped from 48.1±23.6·h-1 to 2.6±2.5·h-1 (p<0.001). There were no significant changes in airway responsiveness (PC20=2.5 (1.4-4.5) mg·ml-1) after CPAP treatment compared with baseline (PC20=2.2 (1.3-3.5) mg·ml-1 (p=0.3)). There was no significant change in FEV1 either. However, the asthma quality of life (QOLAs) of the subjects improved from 5.0±1.2 at baseline to 5.8± 0.9 at the end of the study (p=0.001).

Nocturnal CPAP treatment did not alter airway responsiveness or FEV1 in subjects with stable mild-to-moderate asthma and newly-diagnosed obstructive sleep apnoea. However, nocturnal CPAP treatment did improve asthma quality of life.

Keywords:  Airway responsiveness, asthma, asthma quality of life, CPAP, sleep apnoea




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