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Published online before print September 13, 2006
Eur Respir J 2006, doi:10.1183/09031936.00016006
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ORIGINAL ARTICLE

NT-proBNP reflects right ventricular structure and function in pulmonary hypertension

T-J. Gan 1, G.P. McCann 2, J.T. Marcus 3, S.A. van Wolferen 1, J.W.R. Tiwsk 4, A. Boonstra 1, P.E. Postmus 1, A. Vonk-Noordegraaf 1*

1 Depts of Pulmonary Diseases
2 Cardiology, University Hospitals Leicester, NHS Trust, Leicester, United Kingdom
3 Physics and Medical Technology
4 Clinical Epidemiology and Biostatistics, Institute for Cardiovascular Research ICaR-VU, VU University Medical Center Amsterdam, The Netherlands

* To whom correspondence should be addressed. E-mail: a.vonk{at}vumc.nl.


  Abstract

To investigate whether alterations in NT-proBNP reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment.

30 pulmonary hypertension patients were studied, 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterization and cardiac MRI measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed and on treatment patients at baseline and follow-up with respect to NT-proBNP, hemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r=0.59, p<0.001), right ventricular mass index (r=0.62, p<0.001) and right ventricular ejection fraction (r= -0.81, p<0.001)

NT-proBNP measurements reflect changes in MRI measured right ventricular structure and function in pulmonary hypertension patients. An increased NT-proBNP over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.

Keywords:  Magnetic resonance imaging, N-terminal pro brain natriuretic peptide, pulmonary hypertension, right ventricle




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