Figure 8–
In vivo evaluation of GPact-11a. a) Average salivary secretion from cftr+/+ mice induced by GPact-11a (•; 30 μM, n = 3), GPact-11a (30 μM) with isoprenaline (10 μM, n = 7) (□) or isoprenaline only (▪; 10 μM, n = 19). b) Total salivary secretion from cftr+/+ induced by isoprenaline (Iso; 10 μM), with or without increasing concentrations of GPact-11a. c) Corresponding dose–response curve of GPact-11a. d) Average salivary secretion and e) total salivary secretion from cftr+/+ mice induced by GPact-11a (30 μM) with isoprenaline (10 μM, n = 7) (○) and inhibited by two CFTR inhibitors: GPinh-5a (•; 20 pM, n = 11) and GlyH-101 (▴; 10 μM, n = 4). f) Total salivary secretion from cftr−/− induced by isoprenaline (Iso; 10 μM), with or without increasing concentrations of GPact-11a.