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Published online before print December 5, 2007, 10.1183/09031936.00102107
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Eur Respir J 2008; 31:701-706
Copyright ©ERS Journals Ltd 2008

Left ventricular diastolic dysfunction in idiopathic pulmonary fibrosis: a tissue Doppler echocardiographic study

C. E. Papadopoulos1, G. Pitsiou2, T. D. Karamitsos1, H. I. Karvounis1, T. Kontakiotis2, G. Giannakoulas1, G. K. Efthimiadis1, P. Argyropoulou2, G. E. Parharidis1 and D. Bouros3

1 1st Cardiology Dept, AHEPA University Hospital, 2 Respiratory Failure Unit, Aristotle University of Thessaloniki, Thessaloniki, and 3 Dept of Pneumonology, Medical School, University of Thrace, Alexandroupolis, Greece.

CORRESPONDENCE: D. Bouros, Dept of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis 68100, Greece. Fax: 30 2551076106. E-mail: bouros{at}med.duth.gr

Keywords: Diastole, Doppler echocardiography, idiopathic pulmonary fibrosis, left ventricular dysfunction

Received: August 7, 2007
Accepted November 26, 2007


   ABSTRACT
TOP
 ABSTRACT
MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 Statement of interest
 REFERENCES
 
It was hypothesised that, apart from right ventricular (RV) dysfunction, patients with idiopathic pulmonary fibrosis (IPF) also exhibit left ventricular (LV) impairment, which may affect disease progression and prognosis. The aim of the present study was to evaluate LV performance in a cohort of IPF patients using conventional and tissue Doppler echocardiography.

IPF patients exhibiting mild-to-moderate pulmonary arterial hypertension (mean age 65±9 yrs; n = 22) and healthy individuals (mean age 61±6 yrs; n = 22) were studied. Conventional and tissue Doppler echocardiography were used for the evaluation of RV and LV systolic and diastolic function.

In addition to the expected impairment in RV function, all patients showed a characteristic reversal of LV diastolic filling to late diastole compared with controls (early diastolic peak filling velocity (E)/late diastolic peak filling velocity 0.7±0.2 versus 1.5±0.1, respectively). Patients with IPF also exhibited lower peak myocardial velocities in early diastole (Em; 5.7±1.1 versus 10.3±1.6 cm·s–1, respectively), higher in late diastole (Am; 8.9±1.3 versus 5.5±0.8 cm·s–1, respectively), lower Em/Am ratio (0.6±0.1 versus 1.9±0.5, respectively) and higher E/Em ratio (10.8±3 versus 6±0.6, respectively), all indicative of LV diastolic dysfunction. Moreover, LV propagation velocity was significantly lower in IPF patients (46±13 versus 83±21 cm·s–1, respectively).

Physicians should be aware that patients with idiopathic pulmonary fibrosis exhibit early impairment of left ventricular diastolic function.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing inflammatory lung disease leading progressively to pulmonary hypertension (PH), with increased morbidity and mortality and a mean survival duration after diagnosis ranging 3–5 yrs 1–3.

Right ventricular (RV) dysfunction has been well described in IPF patients, and in several conditions affecting pulmonary circulation, such as primary PH, chronic obstructive pulmonary disease, chronic thromboembolic PH, systemic sclerosis, systemic lupus erythematosus and cystic fibrosis 4–10. Moreover, left ventricular (LV) diastolic dysfunction has been reported in some of these conditions 5–7, 11, 12, mainly as a consequence of RV pressure overload. Nevertheless, the prevalence of LV dysfunction in patients with IPF and mild-to-moderate PH is not known. Importantly, LV dysfunction, if present, could be an additional factor that may further impair exercise performance and affect prognosis early in the course of the disease.

New noninvasive echocardiographic techniques that are relatively load-independent, such as tissue Doppler imaging (TDI) and colour M-mode, have made echocardiography the clinical standard for the assessment of LV diastolic function 13, 14. Regional myocardial velocities and time intervals during systole and diastole can be accurately and reproducibly measured by TDI, permitting the detection of subclinical abnormalities 15. Furthermore, TDI-derived mitral annular velocities are of proven worth in the estimation of LV filling pressures and provision of prognostic information in various cardiovascular diseases 16, 17.

On these grounds, the main aim of the present study was to determine LV and RV systolic and diastolic function in IPF patients.


   MATERIALS AND METHODS
TOP
 ABSTRACT
 MATERIALS AND METHODS
RESULTS
 DISCUSSION
 Statement of interest
 REFERENCES
 
Patients (mean (range) age 66 (53–75) yrs; n = 22 (15 male)) with IPF were studied. The diagnosis of IPF was based on the American Thoracic Society/European Respiratory Society major and minor criteria 18. For high-resolution computed tomographic criteria, appearances compatible with fibrotic idiopathic interstitial pneumonia were required, as previously described 19, 20. The patients were clinically stable and ambulatory at the time of echocardiographic study and were recruited from the outpatient respiratory failure clinic of the Respiratory Failure Unit of the Aristotle University of Thessaloniki (Thessaloniki, Greece) over a period of 18 months. Throughout the study, they continued to receive the same medical treatment.

Patients with a history of significant known coronary artery disease, cardiomyopathy, valvular heart disease, arterial hypertension and symptoms/signs of RV failure were excluded from further evaluation. Furthermore, subjects showing atrial fibrillation and other rhythm abnormalities were excluded from the study.

The control group consisted of 22 age- and sex-matched control subjects without any history of pulmonary and/or cardiac disease. An important technical inclusion criterion of the study was an adequate tricuspid valve regurgitation Doppler signal, in order to assess pulmonary artery systolic pressure in all subjects enrolled in the study.

The ethics committee of the Aristotle University of Thessaloniki approved the present study. All participants gave written informed consent.

Pulmonary function studies
All patients underwent spirometry (Transfer Screen II; Jaeger, Würzburg, Germany) within 1 week of the echocardiographic study according to current guidelines 21. Arterial blood was taken with the patient sitting and breathing room air; blood pH and arterial carbon dioxide and oxygen tension were measured using a commercially available blood gas analyser (ABL5; Radiometer, Copenhagen, Denmark). The functional capacity of subjects was quantitatively measured by performing the 6-min walking test according to current guidelines 22.

Echocardiographic study
All patients and controls underwent a complete echocardiographic study, including two-dimensional (2D), colour-flow and spectral Doppler, as well as TDI using a GE Vingmed Vivid 7 system (GE Vingmed Ultrasound, Horten, Norway). All images were saved digitally in raw data format to magneto-optical disks for offline analysis. Brachial systolic and diastolic blood pressure measurements in the sitting position were performed using a standard mercury sphygmomanometer before each echo evaluation.

Standard 2D and colour-flow Doppler images were obtained using the parasternal long- and short-axis and apical views. M-mode traces were recorded at a speed of 50 mm·s–1. Three consecutive cycles were averaged for every parameter. LV diameter and wall thickness were measured from 2D targeted M-mode echocardiography according to the principal recommendations of the American Society of Echocardiography 23. Resting LV ejection fraction was obtained using a modified Simpson’s biplane method. The RV end-diastolic diameter and RV free-wall thickness were measured from the 2D parasternal long-axis view. RV end-systolic and end-diastolic areas were measured from the apical four-chamber view in order to calculate RV fractional area change. Pulmonary artery systolic pressure (Ppa,sys) was estimated by calculating the maximal velocity of the tricuspid regurgitant jet and then, further using the Bernoulli equation, adding to this value an estimated right atrial pressure based on both the size of the inferior vena cava and the change in diameter of this vessel during respiration 24.

Pulsed Doppler echocardiography for the assessment of the standard diastolic filling velocities of both ventricles was performed using the apical four-chamber view. Thus the peak early diastolic filling velocity (E-wave), peak late diastolic filling velocity (A-wave), their ratio (E/A) and E-wave deceleration time (DT) were recorded. Additionally, colour M-mode was used to obtain the LV propagation velocity (V’p), which serves as another index of LV diastolic function 13. All measurements from three end-expiratory cycles were averaged at a sweep speed of 100 mm·s–1.

Pulsed-wave TDI was used to assess mitral and tricuspid annular velocities. Filters were set to exclude high-frequency signals, and the Nyquist limit was adjusted to a velocity range of 15–20 cm·s–1. Gains were minimised in order to allow for a clear tissue signal with minimum background noise. All TDI recordings were obtained during normal respiration. A 5-mm sample volume was placed at the apical four-chamber view on the lateral corner of the mitral and tricuspid annulus. The peak myocardial velocities during systole, early diastole (Em), late diastole (Am) and their ratio (Em/Am) were recorded at a sweep speed of 100 mm·s–1. Velocities at the septal corner of the mitral annulus were not evaluated due to a possible interaction of the disturbed RV function. Furthermore, the ratio of E to Em (LV E/Em index) was calculated.

Statistical analysis
Data are presented as mean±SD, with frequencies given as percentages. All continuous variables were normally distributed. Differences between groups were assessed using an unpaired t-test. Categorical variables were compared using a Chi-squared test or Fisher’s exact test, as appropriate. Pearson’s correlation coefficients were calculated for pairs of continuous variables. A p-value of <0.05 was considered significant and two-tailed p-values were used throughout.


   RESULTS
TOP
 ABSTRACT
 MATERIALS AND METHODS
 RESULTS
DISCUSSION
 Statement of interest
 REFERENCES
 
Study population characteristics
Of the total 32 IPF patients evaluated and characterised, 22 were finally included in the present study (table 1Go). Five patients were excluded due to an inadequate echocardiographic tricuspid regurgitation Doppler signal, two due to arterial hypertension, one due to severe mitral valve regurgitation, one due to a history of coronary artery disease and one due to atrial fibrillation. The mean time from initial diagnosis of the disease was 9 months.


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  		Table 1— Characteristics of the study population

 
Patients with IPF did not differ significantly from controls in terms of body mass index, smoking habits, baseline cardiac frequency and blood pressure. Table 1Go presents the lung function parameters, resting gas exchange and 6-min walking test data of patients with IPF. Amongst IPF patients at the time of the initial evaluation, five were on acetylcysteine therapy, six on azathioprine, nine on prednisone and five on intermittent oxygen therapy.

RV function assessment
It was documented that IPF patients exhibited impairment of both systolic and diastolic RV function compared with controls (table 2Go). They showed worse RV area change, greater RV chamber dilatation and more RV free-wall hypertrophy, all findings are indicative of a RV remodelling process secondary to increased afterload. This increased afterload was established by the higher Ppa,sys in patients compared with controls. None of the present patients showed a distorted (D-shaped) septum. Additionally a characteristic reversal of E/A ratio was found in IPF patients, reflecting a progressively greater contribution of late diastole to RV filling.


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  		Table 2— Right ventricular echocardiographic parameters in patients with idiopathic pulmonary fibrosis(IPF) and normal controls

 
LV function assessment
A significant difference was observed between the two groups as regards E/A ratio, DT of the E-wave and V’p, reflecting early diastolic filling impairment in this specific population (table 3Go). The two groups did not differ significantly in terms of LV dimensions and systolic function.


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  		Table 3— Left ventricular echocardiographic parameters in patients with idiopathic pulmonary fibrosis(IPF) and normal controls

 
Mitral annular TDI analysis confirmed the presence of LV diastolic dysfunction in IPF patients, with lower LV Em and Em/Am ratios than controls. Moreover, patients with IPF showed higher E/Em ratios than controls. Conversely, peak mitral annular systolic velocity was similar between the two groups.

Correlations
Bivariate correlation analysis revealed significant relations between indices of LV diastolic function and Ppa,sys (table 4Go). The negative correlations of LV E/A ratio (r = -0.61; p<0.001), Em/Am ratio (r = -0.64; p<0.001) and V’p (r = -0.60; p<0.001) with Ppa,sys are of note (fig. 1Go).


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  		Table 4— Bivariate correlations between left ventricular echocardiographic parameters and pulmonary artery systolic pressures

 

Figure 1
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  		Fig. 1— Scatter diagrams showing the correlation between systolic pulmonary artery pressure (Ppa,sys) and left ventricular: a) early diastolic peak filling velocity (E)/late diastolic peak filling velocity (A) ratio (r = -0.61; p<0.001); b) early diastolic peak myocardial velocity (Em)/late diastolic peak myocardial velocity (Am) ratio (r = -0.64; p<0.001); and c) propagation velocity (V’p; r = -0.60; p<0.001). 1 mmHg = 0.133 kPa.

 

   DISCUSSION
TOP
 ABSTRACT
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
Statement of interest
 REFERENCES
 
In the present study, it was demonstrated that patients with clinically stable IPF exhibit not only RV diastolic and systolic dysfunction but also impaired LV diastolic filling. Conversely, LV systolic function seems to be preserved. The present authors believe that the current findings have important implications for the management, and possibly the prognosis, of patients with IPF.

To the best of the present authors’ knowledge, there are no reports in the literature regarding any association between IPF and LV diastolic function. The present findings from both standard Doppler (E/A ratio) and less load-dependent techniques 13, 15, such as colour M-mode (V’p) and TDI (Em, E/Em and Em/Am), suggest that LV diastolic function, particularly early relaxation, is impaired in these patients. Similar disturbances in LV diastolic filling were also reported in previous studies evaluating LV diastolic performance in diseases that mainly affect RV function 5–7, 11, 12. Conversely, LV systolic function, as measured by both standard 2D and TDI echocardiography, was preserved in the present IPF patients, another finding that is in keeping with previous reports evaluating LV systolic function in clinical entities that affect RV performance 4–12.

It is well known that diastolic dysfunction, particularly in the early phase of diastole, is the most common type of LV dysfunction seen in patients with chronic PH 25. This impairment of early relaxation could be explained by different mechanisms. One of these is the distortion of the interventricular septum towards the LV as the RV adapts to pressure or volume overload and increases in size and mass 26. This is less likely in the present study population since PH was only mild to moderate. Secondly, since the RV and LV operate as a syncytium, the diastolic function of one ventricle may influence that of the other, and this phenomenon is well recognised as ventricular interdependence 26, 27. The present finding of significant association between Ppa,sys and LV diastolic function indices underlines the presence of ventricular interdependence in patients with IPF. Finally, compensatory neurohormonal activation seems to occur while RV function declines, and this may influence loading conditions in both ventricles. In more detail, it has been shown, in experimental settings, that peptides with positive inotropic effect, such as angiotensin II, endothelin 1, atrial natriuretic peptide and noradrenalin, are produced. These substances may affect the remodelling process of both ventricles, by changing their loading conditions, inducing collagen synthesis and inhibiting collagen degradation 28, 29.

Patients in the early stages of IPF may demonstrate normal or only slightly elevated Ppa,sys 1–3, but, with the progression of the disease, pulmonary pressure increases dramatically within months 2. Therefore, it is important to determine, in the early stages of the disease, whether these patients suffer from LV diastolic dysfunction, and, further, to investigate, whether or not there is any association with the severity of PH and consequently with IPF disease progression. The present finding of significant associations between LV diastolic function indices and Ppa,sys further supports this hypothesis. If this is the case, echocardiographic parameters of LV diastolic dysfunction could be routinely used for risk stratification and therapeutic monitoring and guidance in such cohorts. Moreover, young patients who have successfully undergone lung transplantation with long-term survival from improved allograft preservation may eventually present with symptomatic left heart failure due to progressive LV diastolic dysfunction. Thus study of LV function in IPF patients after transplantation is warranted.

Limitations
The main limitation of the present study is that the evaluation of PH was performed using Doppler echocardiography and not right heart catheterisation, which is the gold standard method. Moreover, mitral annular TDI recordings could be influenced by overall heart motion and the contraction of adjacent myocardial segments, rendering this modality less sensitive than strain rate imaging 30.

In conclusion, patients with idiopathic pulmonary fibrosis exhibit predominantly type I left ventricular diastolic dysfunction (impaired early relaxation) in addition to the expected impairment of right ventricular systolic and diastolic function. Whether or not left ventricular diastolic abnormalities have prognostic implications for the clinical course of patients with idiopathic pulmonary fibrosis remains to be investigated. The present authors believe that serial echocardiographic measurements, particularly using tissue Doppler imaging, are warranted in this population in order to follow the progression of cardiac dysfunction.


   Statement of interest
TOP
 ABSTRACT
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 Statement of interest
REFERENCES
 
None declared.


   FOOTNOTES
 
Important note: Due to an error, the previous online pdf of this manuscript was incorrect. This is a corrected pdf.


   REFERENCES
TOP
 ABSTRACT
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 Statement of interest
 REFERENCES
 

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