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Eur Respir J 2006; 28:243-247
Copyright ©ERS Journals Ltd 2006

Positional hyperventilation-induced hypoxaemia in pectus excavatum

B. Wallaert1,4, B. Cavestri1, C. Fournier1, R. Nevière2 and B. Aguilaniu3,4

1 Clinique des maladies respiratoires, and 2 Service des Explorations Fonctionnelles Respiratoires, Hôpital Albert Calmette, CHRU, Lille, and 3 HYLAB, Physiologie Clinique & Exercice, Clinique du Mail, Grenoble, France. 4 Authors contributed equally to the work.

CORRESPONDENCE: B. Wallaert, Clinique des Maladies Respiratoires, Hôpital Albert Calmette, Boulevard du Pr. Jules Leclercq, 59037 Lille Cedex, France, Fax: 33 320445768. E-mail: bwallaert{at}chru-lille.fr

Keywords: Clinical exercise testing, foramen ovale, hyperventilation, hypoxaemia, pectus excavatum, shunt

Received: August 18, 2005
Accepted January 25, 2006


   ABSTRACT
TOP
 ABSTRACT
CASE REPORT
 DISCUSSION
 ACKNOWLEDGEMENTS
 REFERENCES
 
The presented case is of a young male (aged 19 yrs) with a pectus excavatum who showed significant exercise intolerance, despite normal pulmonary function at rest, including carbon monoxide diffusing capacity. Clinical exercise testing led to a strong suspicion of a right-to-left shunt due to an abnormally wide alveolo–arterial oxygen gradient (26.4 kPa) at peak oxygen uptake, with severe arterial hypoxaemia (arterial oxygen tension 12.54 kPa).

A right-to-left shunt was confirmed by transoesophageal echocardiography demonstrating a permeable foramen ovale, despite normal right heart pressures. The right-to-left venous flow was mainly dependent on the upright body position and the deep inspiration. Indeed, i.v. dobutamine infusion to selectively affect cardiac output and hyperventilation induced by tidal volume expansion at constant breathing rate in the supine position did not result in arterial oxygen desaturation or shunting. Closure of the foramen ovale through atrial umbrella placement dramatically improved clinical and physiological abnormalities.

This observation demonstrates that a hyperventilatory manoeuvre in the upright position is able to detect a permeable foramen ovale favouring flow in the inferior vena cava in the direction of the abnormal pre-existing atrial channel in a patient with a pectus excavatum.

The current case study reports an unusual physiological phenomenon of hypoxaemia due to hyperventilation. This was due to a rare occurrence of permeable foramen ovale related to positional changes in a young male with pectus excavatum in the absence of elevated right atrial pressure. Cardiovascular shunts resulting from reopening of a permeable foramen ovale are usually associated with increases in right atrial pressures. Positional shunts in relation to particular anatomical abnormalities can, however, develop leading to the transient observation of shunting only upon assumption of various body positions. In this study, a specific case is presented in which a series of manoeuvres confirmed that hyperventilation at rest induced severe hypoxaemia, which could be explained by realignment of the inferior vena cava flow with the foramen ovale.


   CASE REPORT
TOP
 ABSTRACT
 CASE REPORT
DISCUSSION
 ACKNOWLEDGEMENTS
 REFERENCES
 
A 19-yr-old Caucasian male, in whom a marked pectus excavatum evolving since childhood had not been operated upon, presented with exertional dyspnoea upon moderate exercise. He suffered rheumatoid purpura when aged 9 yrs without secondary effects, and was a current nonsmoker and worked as a plasterer. Clinical examination was normal except for the thoracic deformity. The electrocardiogram showed a regular sinus rhythm with a left axis of +80°, and no repolarisation or conduction abnormality with a heart rate of 70 beats·min-1 and a normal arterial blood pressure of 130/70 mmHg. Serum chemistry was normal. Chest radiography showed the thoracic deformity with a vertebral–sternal distance of 4.6 cm, while lung fields were clear. Resting spirometry was normal (table 1Go). Transthoracic echocardiogram at rest showed normal left ventricular diastolic and systolic functions with no evidence of valvular defects. Computed tomography of the thorax showed median and inferior anterior thoracic wall deformity with an index of pectus excavatum severity of 3.87 (ratio of transverse thoracic diameter to the minimal vertebral to sternal length 1). The pleura and lung parenchyma were normal and the heart was displaced to the left (fig. 1Go).


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  		Table 1— Resting pulmonary function data before correction of a right-to-left shunt in a patient with a pectus excavatum

 

Figure 1
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  		Fig. 1— High-resolution thoracic scan at the lower lobes level (provided courtesy of P.M. Rémy-Jardin).

 
A graded cycle-ergometer cardiopulmonary exercise testing (CPET) showed an abnormally low peak oxygen uptake (V’O2,peak) with marked hyperventilation, but no ventilatory limitation as peak ventilation remained at 56% of the predicted maximal ventilation. Peak heart rate was 82% of the maximal predicted heart rate. Exercise resulted in a marked decrease in blood gases from rest (arterial oxygen tension (Pa,O2) 9.57 kPa; arterial oxygen saturation (Sa,O2) 94.5%; alveolar–arterial oxygen tension difference (PA–a,O2) 5.45 kPa) to peak exercise (Pa,O2: 5.08 kPa; Sa,O2: 76.2%; PA–a,O2: 10.64 kPa). The dead space to tidal volume ratio (VD/V’T), and the arterio–alveolar CO2 gradient remained elevated at V’O2,peak (table 2Go).


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  		Table 2— Rest and maximal cycling exercise values in a patient with a pectus excavatum and a permeable foramen ovale from October 2002

 
In view of these exercise-induced pulmonary gas exchange abnormalities, the hypothesis of a right-to-left shunt was proposed. This was further confirmed by a transoesophageal echocardiogram performed under resting sitting conditions showing a largely permeable foramen ovale with no associated intracardiac communication or aortic anomaly and revealing normal right atrial pressures.

In order to assess the mechanism by which the shunt developed, Sa,O2 was monitored during various clinical interventions selectively affecting ventilation or circulation to examine more specifically whether an exercise-induced increase in cardiac output contributed to the observed right-to-left shunt. First, increasing doses of dobutamine were administered intravenously with the patient lying in a semirecumbent position (45°) to affect cardiac output, but not ventilation. This resulted in an increase in heart rate up to 160 beats·min-1, but without evidence of hyperventilation or of any arterial oxygen desaturation.

In contrast, when hyperventilation was induced in the upright position by voluntarily increasing V’T while breathing rate was maintained at 16–18 breaths·min-1, an immediate marked decrease in Sa,O2 was observed, which was reversed upon decreasing V’T to resting values (fig. 2Go). The manoeuvres were repeated while the patient assumed various body positions. Maximal desaturation, and presumably shunting, was observed in the upright position, but this was absent while lying flat, in left or right lateral dorsal decubitus, or in the ventral position.


Figure 2
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  		Fig. 2— Variations of the transcutaneous arterial saturation (Sa,O2; {blacktriangleup}) and tidal volume (V’T; •) during a resting sustained voluntary hyperventilation in the supine (a) and upright (b) positions. Breathing frequency was maintained at 16–18 breaths·min-1.

 
The persistent foramen ovale was then verified through right heart catheterisation, which confirmed normal right heart pressures and revealed a 12-mm foramen ovale diameter, later closed through positioning of a 35-mm Amplatz® umbrella (AGA Medical Corporation, Golden Valley, MN, USA). Finally, graded exercise tests were repeated 3 and 6 months after closure of the shunt which showed an improvement in exercise tolerance pulmonary gas exchange parameters and V’O2,peak (table 3Go). In addition, hyperventilation manoeuvres were repeated in various positions and did not induce oxygen desaturation.


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  		Table 3— Maximal cycle exercise values obtained in a patient with a pectus excavatum before, and 3 and 6 months after transcutaneous closure of a permeable foramen ovale

 

   DISCUSSION
TOP
 ABSTRACT
 CASE REPORT
 DISCUSSION
ACKNOWLEDGEMENTS
 REFERENCES
 
To the best of the current authors’ knowledge, this is the first description of an immediate severe paradoxical hypoxaemia induced by voluntary hyperventilation. This observation in a patient with pectus excavatum may be explained by the hyperventilation-induced alignment of the inferior vena cava flow with the foramen ovale leading to a right-to-left shunt with normal right heart pressures.

The foramen ovale is an embryonic relic that allows the foetal circulation to flow from the right atrium to the left atrium, thereby bypassing the pulmonary vessels. The structure normally closes shortly after birth as left and right atrial pressures rise and fall, respectively. However, an incomplete closure termed "persistent foramen ovale" may also be seen in 9.2–27.3% [2, 3, respectively] of the population. An acquired intracardiac right-to-left shunt via a persistent foramen ovale usually results from an elevated pulmonary pressure leading to an inversion of the normal atrial pressure gradient. In the present case, it cannot be excluded that any increase in pulmonary pressure may occur due to the evolving hypoxia and secondary pulmonary vasoconstriction resulting in some pulmonary hypertension. Clearly, this may not cause the shunt but may add to it. Nonetheless, right-to-left shunts with normal atrial pressures have been described 4, 5, and are characterised by their positional nature, as in the rare "platypnoea-orthodeoxia" syndrome. Two theories have been proposed to explain these right-to-left shunts with normal right atrial pressures 6, 7. First, transitory elevations in right atrial pressure may occur during coughing or in Valsalva manoeuvres leading to a transient pressure gradient and shunting. Examples of these are seen in: 1) elderly subjects; 2) patients with a right atrial myxoma or right-sided infarction; 3) or in the presence of positive end-expiratory pressure ventilation. Secondly, cardiac, thoracic or abdominal structural anomalies, such as those seen in acute or chronic constrictive pericarditis 8, pneumonectomy, right hemi-diaphragm paralysis 9, 10 or cirrhosis of the liver 11, may exist, which redirect the preferential flow from the inferior vena cava towards the interatrial septum and foramen ovale allowing shunting to occur. Therefore, this hypothesis implies two associated conditions. First, there is a persistent foramen ovale and, secondly, the flow from the inferior vena cava is directed onto the atrial septum at the level of the foramen ovale. In the present case, the most likely explanation is that the thoracic deformity of the pectus excavatum alters the anatomical integrity of the mediastinum, such that there is an anterior and leftward rotation of the heart leading to a deviation of the inferior cava flow towards the permeable foramen ovale.

In the present case, the CPET played an essential role in the diagnosis of persistent foramen ovale, since its functional repercussions were largely underestimated by the resting clinical investigation. There are some reports of exercise testing in pectus excavatum 12–23. Results commonly show a reduced V’O2,max which may 12, 13, 15–17 or may not 14, 18–21 be related to the resulting alterations in the exercise-induced ventricular filling and exercise cardiac output to physical deconditioning 22 or to the extent of thoracic deformity 12, 14. Although mitral valve prolapse has been frequently noted with pectus excavatum, to date there is no echocardiographic or heart catheterisation evidence to support the contribution of an impaired exercise cardiac output in the exercise intolerance of these patients 23, 24.

Similarly, there are little data on the exercise blood gases to substantiate a potential role of an impaired gas exchange to the exercise intolerance 12, 22. In the present case, a right-to-left shunt was suspected because of the important alveolo–arterial oxygen gradient at rest and more specifically the exaggerated widening seen upon maximal exercise, which largely exceeds the expected values. A hyperventilation-induced hypoxaemia is an unusual phenomenon, since even in patients with chronic circulatory or respiratory disorders, hyperventilation always leads to an elevation in alveolar oxygen partial pressure and, depending on the normality of the ventilation–perfusion exchanges, a lesser or greater increase in Pa,O2. There have been some reports of hypoxaemia resulting from a reflex hypoventilation following hyperventilation manoeuvres, but no report of hypoxaemia concomitant to hyperventilation 25–27. In the present case, the degree of hypoxaemia may be related to the amplitude of diaphragmatic movements associated with the imposed V’T expansion. This is well illustrated by the absence of arterial desaturation when hyperventilation was performed in the lying position. During inspiration in this position, contraction of the diaphragm pushes the abdominal contents downwards and backwards increasing the longitudinal and transverse diameters of the thorax. In contrast, in the upright position, the increase in V’T expansion during hyperventilation exaggerates the stretching of the deviated inter-auricular septum, thereby favouring aligment of the inferior cava and the potentially permeable foramen ovale.

The right-to-left shunt was immediately corrected by placement of an intracardiac umbrella. This correction resulted in a marked improvement in exercise tolerance as seen from the increase in V’O2,peak, the reduction in peak minute ventilation and VD/V’T, and the dramatic improvement of the alveolar–arterial O2 gradient (table 3Go). Further improvement in the peak exercise Pa,O2 and alveolar–arterial O2 gradient upon the CPET performed 6 months after closure of the foramen ovale may be taken to suggest that local atrial fibrosis solidified umbrella placement to eliminate the persistence of a small residual right-to-left shunt upon immediate placement of the umbrella.

The present case demonstrates that a hyperventilation manoeuvre in the situation of a pre-existing thoracic deformity may reveal the presence of a patent foramen ovale, which might be due to the channelling of the inferior vena cava flow towards the intra-atrial communication, thereby revealing an arterial desaturation, the degree of which is modified by the amplitude of the movement of the diaphragm.


   ACKNOWLEDGEMENTS
TOP
 ABSTRACT
 CASE REPORT
 DISCUSSION
 ACKNOWLEDGEMENTS
REFERENCES
 
The authors would like to thank H. Perrault (McGill University, Montreal, QC, Canada) for his contribution to the critical review and presentation of this manuscript.


   REFERENCES
TOP
 ABSTRACT
 CASE REPORT
 DISCUSSION
 ACKNOWLEDGEMENTS
 REFERENCES
 

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