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Eur Respir J 2004; 24:116-121
Copyright ©ERS Journals Ltd 2004

Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms

M.I. Gunnbjörnsdóttir1, E. Omenaas2, T. Gíslason3, E. Norrman4, A-C. Olin5, R. Jõgi6, E.J. Jensen7, E. Lindberg1, E. Björnsson3, K. Franklin2, C. Janson1 and on behalf of the RHINE study group

1 Dept of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala,, 4 Dept of Pulmonary Medicine and Allergology, University Hospital of Northern Sweden, Umeå,, 5 Section of Occupational and Environmental Medicine and Section of Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden,, 2 Dept of Thoracic Medicine and Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway, 3 Dept of Allergy and Respiratory Medicine, Landspitali University Hospital, Reykjavik, Iceland, 6 Foundation Tartu University Clinics, Lung Clinic, Tartu, Estonia, 7 Dept of Respiratory Diseases, University Hospital of Aarhus, Aarhus, Denmark

CORRESPONDENCE: M.I. Gunnbjörnsdóttir, Dept of Medical Sciences: Respiratory Medicine and Allergology, Akademiska Sjukhuset, SE 751 85 Uppsala, Sweden. Fax: 46 186110228. E-mail: maria.gunnbjornsdottir@medsci.uu.se

Keywords: Asthma, epidemiology, gastro-oesophageal reflux, habitual snoring, obesity, respiratory symptoms

Received: April 15, 2003
Accepted January 23, 2004

The study was supported financially by the Icelandic Research Council, the Swedish Heart and Lung Foundation, the Vårdal Foundation for Health Care Science and Allergy Research, the Swedish Association against Asthma and Allergy, the Norwegian Research Council, the Norwegian Asthma and Allergy Association, the Danish Lung Association and the Estonian Science Foundation.


   Abstract
TOP
 Abstract
Methods
 Results
 Discussion
 References
 
Several studies have identified obesity as a risk factor for asthma in both children and adults. An increased prevalence of asthma in subjects with gastro-oesophageal reflux (GOR) and obstructive sleep apnoea syndrome has also been reported. The aim of this investigation was to study obesity, nocturnal GOR and snoring as independent risk factors for onset of asthma and respiratory symptoms in a Nordic population.

In a 5–10 yr follow-up study of the European Community Respiratory Health Survey in Iceland, Norway, Denmark, Sweden and Estonia, a postal questionnaire was sent to previous respondents.

A total of 16,191 participants responded to the questionnaire. Reported onset of asthma, wheeze and night-time symptoms as well as nocturnal GOR and habitual snoring increased in prevalence along with the increase in body mass index (BMI). After adjusting for nocturnal GOR, habitual snoring and other confounders, obesity (BMI >30) remained significantly related to the onset of asthma, wheeze and night-time symptoms. Nocturnal GOR was independently related to the onset of asthma and in addition, both nocturnal GOR and habitual snoring were independently related to onset of wheeze and night-time symptoms.

This study adds evidence to an independent relationship between obesity, nocturnal gastro-oesophageal reflux and habitual snoring and the onset of asthma and respiratory symptoms in adults.

The prevalence of both asthma and obesity is increasing worldwide 1–3. Several studies have found that obesity is a risk factor for asthma in both children and adults 4–7. An increased prevalence of asthma in subjects with gastro-oesophageal reflux (GOR) 8, 9 and obstructive sleep apnoea syndrome (OSAS) 10 has also been reported. As both GOR and OSAS are related to obesity, it is possible that this may explain the association between obesity and asthma. However, intervention studies do indicate that obesity, GOR and OSAS are independent risk factors of asthma. Weight reduction in obese asthmatics was found to reduce airway obstruction, as well as peak expiratory flow (PEF) variability 11. Conversely, medical and surgical anti-reflux treatment reduces asthma symptoms and asthma medication requirement, even though there is little or no effect on lung function 12, 13. Furthermore, patients with both OSAS and coexisting asthma showed significant improvement in asthma symptoms and recorded daily PEF rates when treated for sleep apnoea with nasal continuous positive airway pressure 14.

The aim of this study was to evaluate obesity, nocturnal GOR and habitual snoring as independent risk factors for the onset of asthma and respiratory symptoms in Northern European adults. If obesity was associated with increased risk of asthma onset, the study would be taken one step further; to assess whether this could be explained by reported nocturnal GOR and/or habitual snoring.


   Methods
TOP
 Abstract
 Methods
Results
 Discussion
 References
 
The study design and target population
Respiratory Health in Northern Europe (RHINE) is a follow-up study of participants in the European Community Respiratory Health Survey (ECRHS) stage I, which took place in 1990–1994 15.

In stage I of the ECRHS, males and females aged 20–44 yrs were randomly selected from the population register in each participating centre. A postal questionnaire was sent to 3,000–4,000 subjects at each centre. Participating centres in Northern Europe were located in the following cities: Reykjavik (Iceland); Bergen (Norway); Aarhus (Denmark); Gothenburg, Uppsala, Umeå (Sweden); and Tartu (Estonia). The average response rate for the ECRHS stage I in the Nordic centres was 83.7%.

The RHINE study was conducted in 1999–2001 in the same seven Nordic centres. A postal questionnaire was sent to eligible subjects (n=21,802). Subjects not responding to the first mailing received two reminders. A total of 16,191 (74.3%) subjects answered the questionnaire.

Responses from the RHINE study were used in the calculations when analysing risk factors. The responses from stage I of the ECRHS were also taken into account when defining the onset of asthma and respiratory symptoms.

Case definition
An asthma case was defined by answering "yes" to one or both of the questions: "Have you had an attack of asthma in the last 12 months?" and/or "Are you currently taking any medicine (including inhalers, aerosols or tablets) for asthma?". Onset of asthma was defined as answering "no" to both questions in 1990–1994 but "yes" to one or both questions in 1999–2001.

Wheeze was defined as answering "yes" to the question: "Have you had wheezing or whistling in your chest at any time in the last 12 months?" Onset of wheeze was defined as answering "no" to this question in 1990–1994 and answering "yes" to the question in 1999–2001.

Night-time symptoms were defined as answering "yes" to one or both of the questions: "Have you been woken by an attack of shortness of breath at any time in the last 12 months?" and/or "Have you woken up with a feeling of tightness in your chest at any time in the last 12 months?". Onset of night-time symptoms were defined as answering "no" to both questions in 1990–1994 but answering "yes" to either or both questions in 1999–2001.

In the present study, the "onset of respiratory symptoms" is used as a synonym for onset of wheeze and night-time symptoms.

Body mass index
Body mass index (BMI) was calculated for each subject as weight in kilograms divided by the squared height in meters (kg·m–2). Four groups were defined with BMI 20–<25 used as reference. Subjects with BMI <20, 25–<30 and ≥30 are referred to, respectively, as being underweight, overweight and obese.

Gastro-oesophageal reflux and snoring
The questionnaire contained seven multiple-choice questions in which the subjects were asked to estimate the frequency of various sleep-related symptoms on the following 5-point scale: never; less than once a week; 1–2 nights a week; 3–5 nights a week; and almost every night.

The question asked regarding GOR was: "Do you have heartburn or belching when you have gone to bed?". Subjects reporting these symptoms ≥1–2 nights per week are, in this study, referred to as reporting nocturnal GOR 16. The question asked regarding snoring was: "Do you snore loudly and disturbingly?" Subjects reporting snoring ≥3–5 times per week are referred to as reporting habitual snoring.

Smoking and rhinitis
The questions asked were: "Are you a smoker?" and "Are you an ex-smoker?" Subjects were divided into three groups: smokers, exsmokers and never-smokers, based on self-reported smoking status 1999–2001. Participants answering "yes" to the question: "Do you have any nasal allergies including hay fever?" in 1999–2001 are referred to as having rhinitis.

Statistical analysis
The Chi-squared test and test for trend were used to calculate associations between two nominal variables (univariate analysis). ANOVA with test for equality of variance was used when comparing continuous data with nominal. Multiple logistic regression analyses were performed to analyse the influence of several risk factors, and the results are presented as adjusted odds ratios (OR) with a 95% CI. In order to detect heterogeneity between centres, the adjusted ORs were calculated separately for each centre. Average effect estimates were derived and potential heterogeneity between centres was examined using standard methods for random-effects meta-analysis. A p-value of <0.05 was regarded as statistically significant.


   Results
TOP
 Abstract
 Methods
 Results
Discussion
 References
 
A total of 16,191 subjects participated in the study (a response rate of 74.3%) and 8,587 (53.0%) of the participants were female. The mean±sd age of the participants was 39.6±7.1 yrs. The mean follow-up time was 7.9 yrs. The mean±sd BMI was 24.8±4.0 kg·m–2. The characteristics of the study population are given in table 1Go.


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  		Table 1 Characteristics of the study population

 
Compared to the responders in the follow-up, the nonresponders were younger (30.8±7.1 versus 31.9±7.1 yrs, p<0.0001), reported wheeze more often (24.1% versus 21.5%, p<0.0001), had more night-time symptoms in 1990–1994 (16.1% versus 13.9%, p=0.001) and were more often male (53.4% versus 46.6%, p=0.001). No significant difference was found between responders and nonresponders, however, when looking at the prevalence of asthma in 1990–1994 (4.3% versus 4.7%, p=0.20).

The study population, stratified according to BMI groups, is presented in table 2Go. Half of the population had a BMI between 20–<25 kg·m–2. Obesity and being overweight was more common in males, as 51.7% of males had a BMI >25 kg·m–2 compared to 27.1% of females (p<0.0001). Subjects in the lowest BMI group were significantly younger (p<0.0001). The prevalence of nocturnal GOR increased with higher BMI, and the same pattern could be seen with habitual snoring. Reported onset of asthma, wheeze and night-time symptoms increased in prevalence along with the BMI gradient, with the highest values in subjects with a BMI >30 kg·m–2.


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  		Table 2 Characteristics of participants in relation to body mass index (BMI)

 
As presented in figure 1Go, the prevalence of asthma onset gradually increased with increasing BMI in both males (p for trend=0.02) and females (p for trend=0.03). Similarly, subjects reporting nocturnal GOR (fig. 2Go) and habitual snoring (fig. 3Go) exhibited a higher prevalence of asthma and respiratory symptom onset.



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  		Fig. 1.— The prevalence of asthma onset in relationship to body mass index (BMI) in males and females. {square}: BMI <20; : BMI >25–<30; : BMI >25–<30; {blacksquare}: BMI >30. #: p<0.02; : p<0.03.

 


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  		Fig. 2.— The prevalence of asthma and respiratory symptom onset in subjects with () and without ({square}) nocturnal gastro-oesophageal reflux. #: p<0.0001.

 


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  		Fig. 3.— The prevalence of asthma and respiratory-symptom onset insubjects with () and without ({square}) habitual snoring. #: p<0.0001; : NS.

 
The results of the multivariate logistic regression analyses are presented in table 3Go. All values were adjusted for age, centre, smoking, rhinitis and other variables in the table. Obesity and nocturnal GOR were independent risk factors for the onset of asthma, wheeze and night-time symptoms. Habitual snoring was, however, found to be an independent risk factor for the onset of wheeze and night-time symptoms, but not for the onset of asthma. The OR for the onset of asthma and respiratory symptoms in obese subjects (BMI >30kg·m–2) changed only slightly after adjustments for nocturnal GOR and/or snoring (table 4Go). In the same manner, the OR for nocturnal GOR and habitual snoring was only slightly affected when adjusting for obesity.


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  		Table 3 Odds ratios (OR) for asthma and respiratory symptom onset

 

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  		Table 4 Odds ratios (OR) for asthma and respiratory symptom onset in subjects with body mass index (BMI) >30

 
The sex of the individual did not affect the associations between the onset of asthma, respiratory symptoms, BMI, nocturnal GOR or habitual snoring. Neither were there any significant interactions between BMI groups, nocturnal GOR and habitual snoring in the association of these variables with onset of asthma or respiratory symptoms.

The association between onset of asthma and respiratory symptoms and obesity, nocturnal GOR and snoring in the different centres was also assessed by meta-analysis. The estimates were very similar to those derived when analysing the pooled data, and no significant centre heterogeneity was detected for any of the risk factors (obesity, nocturnal GOR and habitual snoring) in relation to the onset of asthma or respiratory symptoms.


   Discussion
TOP
 Abstract
 Methods
 Results
 Discussion
References
 
The central findings in this study were that subjects reporting onset of asthma and respiratory symptoms had higher prevalence of obesity, nocturnal GOR and habitual snoring than subjects not reporting onset of asthma or respiratory symptoms. After adjustments for possible confounders, obesity and nocturnal GOR were found to be independent risk factors for the onset of asthma and respiratory symptoms. Habitual snoring was found to be an independent risk factor for the onset of respiratory symptoms but not for asthma. These risk factors affected males and females in the same way.

Many studies have reported an association between asthma and obesity in children 17–21. An association between increasing BMI and adult-onset asthma in females was found in the Nurses' Health Study II, and the same study also found that weight gain after 18 yrs was also strongly associated with incident asthma 6. Two research groups have recently reported associations between weight gain, obesity and asthma diagnosis in females, but not in males 5, 22. The Italian National Health Survey did, however, find an increased risk for asthma in males with BMI <20 and BMI >30, but in females the association was more linear 23. Young et al. 24 found a linear relationship between BMI and the risk of having asthma in both sexes. The current study found an association between an increasing BMI and onset of asthma in both males and females. This is an important finding which can probably be explained by the large study sample, which offers sufficient incident cases to demonstrate such a relationship in both sexes.

Two publications have reported an association between obesity, asthma and respiratory symptoms. The former found that even though moderate (BMI 30–34.9) and severe obesity (BMI >35) was a risk factor for asthma and wheeze in the last 12 months; the level of atopy, airway hyperresponsiveness and airway obstruction was not higher in those two groups 25. The latter found obesity to be a risk factor for self-reported asthma, bronchodilator use and dyspnoea with exertion, but obese participants had the lowest risk for significant airflow obstruction 26. These data suggest that obstructive airway disease in obese subjects might be overdiagnosed. As the current study is questionnaire-based with no objective measurement, such as spirometry and/or methacholine test, it can be assumed that the same applies for the study population, and may possibly bias the results. The prevalence of atopy in the present study population is also unknown, but adjustment for rhinitis was carried out.

The association between obesity and onset of asthma was relatively unaffected by adjustment for nocturnal GOR and habitual snoring. This in turn indicates that the association is probably not solely explained by the higher prevalence of GOR and obstructive sleep apnoea in obese subjects. Other explanatory mechanisms have been suggested, such as various environmental factors like birth weight, diet and physical activity. Obesity may also affect asthma by enhancing the immune response, by genetic mechanisms or by hormones 27.

Nocturnal GOR was an independent risk factor for onset of asthma and respiratory symptoms in the current study. An association between GOR and asthma has been identified in children and adults, but a cause–effect relationship between the two diseases has not been established 28. It is also known that the prevalence of GOR is higher among asthma patients than it is among individuals without asthma, and that anti-reflux treatment can reduce asthma symptoms 29. One study found gastric ulcer and obesity as independent risk factors for asthma 24. As no obvious associations are known to exist between asthma and gastric ulcer, the authors of the paper speculated that perhaps some of those responding positively to questions on gastric ulcer also suffered from GOR. Several explanatory mechanisms as to the association between asthma and GOR have been suggested, such as vagally-mediated bronchoconstriction, heightened bronchial reactivity and microaspiration 30.

Habitual snoring is a common condition with a prevalence of 16–48% among males and 8–27% among females 31–34, and is one of the main symptom of OSAS. Obesity and GOR are common in subjects with OSAS 35, 36 and bronchial hyperresponsiveness can be found in nonasthmatics with this syndrome 37. Habitual snoring was independently associated with onset of respiratory symptoms in the current study, even after adjusting for obesity and nocturnal GOR. This suggests a relationship between obstruction in the upper and lower airways, but the mechanisms for these associations remain unclear.

There are several methodological issues that must be addressed regarding this study. It is not possible to determine if obesity increases the risk for onset of asthma or if subjects become obese after their asthma becomes active, because of the cross-sectional nature of the study. The direction of the cause–effect relationship between the two variables or whether there is a true cause–effect relationship cannot be determined. This applies to all other respiratory symptoms and associations found in the study. Another study indicates that asthma itself may increase the risk of experiencing GOR 38. The cause–effect relationship between reflux and asthma thus remains unclear.

The study is questionnaire based with no objective measurement. This makes it impossible to determine if subjects reporting onset of asthma actually are asthmatics. The questions used in the current study have nevertheless been evaluated in other surroundings and have been found to have high specificity for asthma 39.

It is also possible that an unmeasured variable may have confounded the results. It was nevertheless possible to control for the most important covariants, such as age, centre, smoking and rhinitis. The study is multi-centred and in five different languages, which introduces a possible translation bias. A high internal consistency in the ECRHS questionnaire has however been found, which suggests that international comparisons are not affected by errors due to cross-cultural variations in reporting of symptoms 40. BMI was calculated from self-reported weight and height, which can possibly induce error. Self-reported height and weight can however be used in epidemiological studies where the subjects are ≤60 yrs old 41. As the subjects participating in this study are 24–53 yrs, it is proposed that this method of calculating BMI does not cause any significant error in the study results.

The average respond rate was 74.3%, but only 60% of the original population responded to both questionnaires, which could, in turn, induce bias. In the first survey, nonresponders were younger males with higher prevalence of wheeze and night-time symptoms than responders. This difference might bias the results, but no significant difference was found in the prevalence of asthma between responders and nonresponders.

The strength of this study lies in the large sample size, which gives sufficient power to control for many potential cofounders simultaneously. The study is population based, which suggests that findings can be applied to other similar populations. The validity of the results is to some extent strengthened by the fact that there were no significant differences in the factors associated with asthma or respiratory symptoms, when the results from each study centre were compared.

In conclusion, an independent relationship between onset of asthma and respiratory symptoms with obesity and nocturnal gastro-oesophageal reflux in both males and females was found. Habitual snoring was an additional risk factor for onset of respiratory symptoms, but not for onset of asthma. This indicates that the previously described association between obesity and asthma is not only related to a higher prevalence of gastro-oesophageal reflux and snoring in obese subjects, and must be explained by other mechanisms.


   References
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 Discussion
 References
 

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M I Gunnbjornsdottir, K A Franklin, D Norback, E Bjornsson, D Gislason, E Lindberg, C Svanes, E Omenaas, E Norrman, R Jogi, et al.
Prevalence and incidence of respiratory symptoms in relation to indoor dampness: the RHINE study
Thorax, March 1, 2006; 61(3): 221 - 225.
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F Gomez Real, C Svanes, E H Bjornsson, K Franklin, D Gislason, T Gislason, A Gulsvik, C Janson, R Jogi, T Kiserud, et al.
Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey
Thorax, January 1, 2006; 61(1): 34 - 40.
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 ChestHome page
Y. Chen, D. Rennie, Y. Cormier, and J. Dosman
Sex Specificity of Asthma Associated With Objectively Measured Body Mass Index and Waist Circumference: The Humboldt Study
Chest, October 1, 2005; 128(4): 3048 - 3054.
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 ThoraxHome page
C Svanes, F G. Real, T Gislason, C Jansson, R Jogi, E Norrman, L Nystrom, K Toren, and E Omenaas
Association of asthma and hay fever with irregular menstruation
Thorax, June 1, 2005; 60(6): 445 - 450.
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I S Olafsdottir, T Gislason, B Thjodleifsson, I Olafsson, D Gislason, R Jogi, and C Janson
C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study
Thorax, June 1, 2005; 60(6): 451 - 454.
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 Am. J. Respir. Crit. Care Med.Home page
K. A. Franklin, T. Gislason, E. Omenaas, R. Jogi, E. J. Jensen, E. Lindberg, M. Gunnbjornsdottir, L. Nystrom, B. N. Laerum, E. Bjornsson, et al.
The Influence of Active and Passive Smoking on Habitual Snoring
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 799 - 803.
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