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Copyright ©ERS Journals Ltd 2003
Sex differences in lung vulnerability to tobacco smoking
1 Nord-Trøndelag Health Study Research Centre, Norwegian University of Science andTechnology (NTNU), Verdal, 2 Dept of Community Medicine and General Practice, NTNU, Trondheim, 3 Dept of Thoracic Medicine, University of Bergen, Bergen, Norway. 4 Dept ofRespiratory Medicine and Allergology, University Hospital, Lund, Sweden
CORRESPONDENCE: A. Langhammer, Nord-Trøndelag Health Study Research Centre, Norwegian University of Science and Technology, Neptunveien 1, N-7650 Verdal, Norway. Fax: 47 74075181. E-mail: arnulf.langhammer@medisin.ntnu.no
Keywords: lung function, respiratory symptoms, self-rated health, sex, tobacco smoking
Received: June 20, 2002
Accepted January 29, 2003
This
study was supported by the Norwegian Research Council and AstraZeneca.
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Abstract |
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 TOP Abstract Materials and methodsResultsDiscussionAcknowledgementsReferences |
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Studies have indicated that females are more vulnerable to the deleterious effect of tobacco smoking than males. The current study aimed to investigate the associations between tobacco smoking and reported respiratory symptoms, self-rated health, and lung function by sex.
In 1995–1997 65,225 subjects aged 
20 yrs (71%
of invited) attended for screening within the Nord-Trøndelag
Health Study. Among these, 10,941 subjects selected randomly or because they
reported having asthma or asthma-related symptoms, participated in the
Bronchial Obstruction in Nord-Trøndelag study consisting of spirometry
and a personal interview.
Tobacco smoking was associated with increased prevalence of respiratory symptoms, reduced lung function, and lower score on global self-rated health (SRH). Adjusted for smoking burden and lung function, females had a higher risk for reporting respiratory symptoms and lower SRH compared with males. Further, smoking burden was associated with a larger relative reduction in expiratory lung function in females than in males.
Females reported more symptoms and lower self-rated health compared with males with similar smoking burden. Even if smoking in females was associated with a larger reduction in per cent predicted lung function compared with males, this does not fully explain the higher symptom prevalence in females.
Some studies have reported higher vulnerability to the deleterious effects of tobacco smoking in females compared with males. These results include negative effect on lung growth 1, lower lung function in adulthood 2, increased bronchial responsiveness 3, higher rate of hospitalisation forchronic obstructive pulmonary disease 4, and higher risk of respiratory symptoms 5. There are, however, conflicting reports on sex differences for the negative effect on lung function of tobacco smoking 2, 6. Even if there are sex-related differences in perception, reporting and interpretation of respiratory symptoms and diseases 7, a symptom like shortness of breath is found to be associated with quality of life and to predict mortality equally well in both sexes 8. It has therefore been proposed that respiratory symptoms are more related to general health in females and are more specific for respiratory and cardiac diseases in males.
The objective of this study was to analyse the effect of tobacco smoking on lung function, and to study the association between respiratory symptoms, lung function and global self-rated health (SRH) in males and females.
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Materials and methods |
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TOPAbstractMaterials and methodsResultsDiscussionAcknowledgementsReferences |
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In 1995–1997 all inhabitants of the Nord-Trøndelag County, Norway, aged
20 yrs were invited to the adult part of the Nord-Trøndelag
Health Study (HUNT). The invitation included a comprehensive questionnaire
on health, diseases, symptoms and risk factors. At the screening station,
a further questionnaire with more disease-specific questions was asked.
Among the participants in the HUNT study, two groups were invited to the Bronchial
Obstruction in Nord-Trøndelag (BONT) study, phase I including:
1) a 5% random sample of the total population; and 2) a symptom
group with positive answers to questions either on ever-asthma, ever-use
of asthma medication or attacks of wheezing or breathlessness during the last
12 months. A third questionnaire focusing onrespiratory symptoms was also
given to those invited to the BONT study and those reporting persistent cough
in questionnaire I (fig. 1
).
The questions concerning respiratory illnesses, diseases and smoking habits
have been published previously 5.
The question on SRH; "How is your health at the moment?" could
be answered as "poor", "not well", "well"
and "very well" 9.
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The BONT study phase I consisted of flow/volume spirometry and a structured, personal interview on respiratory symptoms, diagnosis and treatment. Flow/volume spirometry was recorded with three pneumotachographs (MasterScope spirometer, version 4.15; Erich Jaeger GmbH, Wuerzburg, Germany) by trained staff in accordance with recommendations by the American Thoracic Society 10. The predicted forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated using prediction equations estimated for this population 11.
The study was approved by the Regional Committee for Ethics in Medical Research and the Norwegian Data Inspectorate.
Analysis
Descriptive data are presented as mean±sd as well as
mean and 95% confidence interval (CI). Analyses of variance
were used for continuous data. Linear regression analysis was used to evaluate
the impact of independent variables on lung function, and logistic regression
to evaluate the impact of independent variables on the risk of symptom reporting
and global SRH. Interactions between the independent variables were tested
and the results are reported where statistically significant. SRH was used
as a dependent variable both inseparate models for each level of SRH and as
one dichotomised variable (negative=poor or not well, positive=well
or very well) in the logistic regression models. Sex differences were
tested including interactions in the regression models. In the analysis of
the association between tobacco smoking and lung function, only never-
and current smokers were included. For linear regression models, the assumptions
of linearity and homogeneity were tested, and goodness of fits for logistic
regression models were tested with Hosmer Lemeshow tests. All p-values
were two-tailed, and a p<0.05 was considered significant.
Estimation of the prevalence of symptoms in the population was restricted to the 5% random sample. In the further analyses the group reporting respiratory symptoms was also included.
Subjects, who reported both "ever-asthma" (having had asthma at one time or another) and attacks of wheezing or breathlessness during the last 12 months, were defined as having current asthma. Chronic bronchitis was defined as reported cough with phlegm in periods of at least 3 months during the last 2 yrs.
The smoking status was classified as never-smokers (never smoked
daily), exsmokers (ceased smoking 1 yrs earlier)
and current daily smokers. The latter two groups were classified as ever-smokers.
Number of pack-yrs was calculated as: years of smoking multiplied by number
of cigarettes a day divided by 20. Those reporting only current pipe smoking (0.9%
males and 0.1% females) or cigar/cigarillos smoking (0.2%
males and 0.1% females) were categorised as current daily smokers,
but number of pack-yrs could not be estimated.
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Results |
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TOPAbstractMaterials and methodsResultsDiscussionAcknowledgementsReferences |
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Participants and smoking history
In total, 65,225 subjects (71%) attended the HUNT study and 10,941 subjects participated in BONT phase I (fig. 1
). The 5% random sample did
not differ from the total screening population regarding demographical characteristics,
respiratory symptoms and smoking habits except for a slightly higher prevalence
of reported daily coughing (17.6 versus 15.8%),
chronic bronchitis (5.1 versus 4.0%) and never-smokers (41.1 versus 38.3%) in males, in the random sample (all p<0.05).
Amongst all participants at the screening, there was a minor difference
in prevalence of current smokers among females and males (30.6 versus 29.6%, p=0.01), and in the random and symptom group,
a corresponding but nonsignificant difference was found (table 1). Amongst all participants, ever-smoking
males reported a higher daily cigarette consumption (13.1 versus 9.7 cigarettes) and had started to smoke at a younger age (18.4 versus 19.8 yrs) compared with females (p<0.001).
The current smoking females were significantly younger than males (45.7 versus 50.2 yrs), in contrast to never-smokers (52.7 versus 44.4 yrs) (both p<0.01). Further, 64%
of all participants reported exposure to passive smoking in childhood and
60% reported this in adulthood. Amongst never-smokers, 48%
of females and 35% of males reported exposure to passive smoking in
adulthood (p<0.01).
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Respiratory symptoms, diagnosis and tobacco smoking
Adjusted for age and body mass index (BMI), females had a significantly higher risk per 10 pack-yrs of reporting attacks of wheezing or breathlessness (odds ratio (OR) 1.38 versus 1.25), current asthma (1.30 versus 1.15), and persistent cough (1.48 versus 1.32) (all p<0.01) compared with males, when allparticipants in the main screening were included in the analyses 5. A similar relationship was found among participants at BONT phase I, and statistically significant differences were found even when an intermediate variable, such as lung function (FEV1 % predicted) and the interaction term sex * FEV1 % pred were included in the model (data not shown). Analyses of the interview data revealed that females, adjusted for age and BMI, had significantly greater risk than males of reporting wheezing (OR 1.38 (95% CI 1.35–1.45) versus 1.25 (1.20–1.30)) and breathlessness (1.18 (1.11–1.24) versus 1.08 (1.04–1.12)) per 10 pack-yrs. Inclusion of the group (random sample or symptom group) as an independent variable did not alter these results.
Exposure to tobacco smoking in childhood was significantly associated with the risk of reporting attacks of wheezing or breathlessness in females (1.20 (1.10–1.30)) but not in males, when age, pack-yrs, BMI, and smoking category (never, ex- or current smoker) were included as independent variables. Exposure to passive smoking after the age of 20 yrs, included in a similar model, was also associated with increased risk of these symptoms, but in this case, no difference with sex was found (1.23 (1.16–1.31)).
In the random sample, 8.7% of both females and males reported doctor-diagnosed asthma. Further, doctor-diagnosed chronic bronchitis/emphysema was reported by 2.3% females and 4.0% males (p<0.01), but the difference became statistically insignificant when adjusted for BMI, FEV1 % pred and pack-yrs. Smoking burden was not associated with being given the diagnosis of asthma by a doctor, but the OR for thediagnosis of chronic bronchitis/emphysema was 2.3 per pack-yr in both sexes.
Lung function and exposure to tobacco smoking
Tobacco smoking was associated with lower lung function in all age groups,
the greatest decline being found in current smokers (fig. 2a and b). Correspondingly, passive smoking
after the age of 20 yrs, adjusted for age and pack-yrs, was associated
with 1.5% lower FEV1 % in both sexes (p<0.05),
compared with nonexposed. When the analyses were restricted to never-smokers,
a minor and nonsignificant (p=0.07) lower FEV1 %
pred was found in females exposed to passive smoking compared with those without
such exposure (fig. 2b).
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)
and not exposed (
) to passive smoke, and among ever-smokers (•)
in a) males and b) females.Decreased FVC, FEV1, FEV1/FVC (fig. 3
), and forced expiratory flow at 25–75%
of forced vital capacity (FEF25–75) (data
not shown) were associated with tobacco smoking in ever smokers according
to both pack-yrs and current daily cigarette consumption (p<0.01
for trend). No sex difference in absolute values was found for any of
the lung function parameters and this was independent of age. Age and height
adjusted FEV1, FVC and FEF25–75 were associated
with a reduction of 12, 10, and 27 mL·s–1 per
pack-yr, respectively. However, this means that females have a larger
reduction in these lung function parameters in % pred terms than males.
One pack-yr was associated with 0.52 and 0.32% lower FEV1 % pred in females and males (p<0.001), respectively,
and the corresponding figures for FVC% reduction were 0.28 and 0.16% (p<0.001).
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) by pack-yrs
in males (–) and females (
) in the total Bronchial
Obstruction in the Nord Trøndelag study group (random sample 2,791
subjects and symptom group 8,150 subjects).Respiratory symptoms, diagnosis, and self-rated health by lung function and sex
Females reported a higher prevalence of wheezing or breathlessness and coughing, independent of FEV1 % pred, compared with males for both the total BONT sample (fig. 4
)
and when the analyses were restricted to only the 5% random sample.
Further, females aged >60 yrs had significantly higher FEV1 % pred compared with males, regardless of reporting respiratory
symptoms or doctor-diagnosed respiratory disease (p<0.01) (fig. 5).
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In the total BONT sample, SRH was reported to be "poor" in 2% and "very well" in 16% of cases, independent of sex. Independent of lung function, the category "well" was reported by fewer females than males (23.2 versus 27.8%), with reciprocal results in the category "not very well" (both p<0.01). A similar pattern was found for SRH, dichotomised in those reporting "positive" and "negative" score by FEV1 % pred adjusted for age and pack-yrs (fig. 6
).
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A decreased score in SRH was associated with specific respiratory symptoms, including attacks of wheezing, breathlessness, or cough, without any difference with sex. These results were not significantly influenced by pack-yrs, level of education and BMI as covariates in the model.
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Discussion |
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TOPAbstractMaterials and methodsResultsDiscussionAcknowledgementsReferences |
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A higher proportion of females reported respiratory symptoms compared with males, adjusted for smoking burden and lung function. Further, reporting of respiratory symptoms was associated with poorer SRH in both sexes, but females reported poorer SRH compared with males independent of lung function. The results from this study confirm previous findings of a dose-dependent increase in prevalence of respiratory symptoms and a corresponding negative effect on lung function with tobacco smoking 12. However, females had a larger reduction in lung function in terms of % pred than males.
BONT was part of a comprehensive cross-sectional study of a complete adult population, including a 5% representative random sample of the total population and a symptom group, both with high attendance rate 5. A study of nonresponders at the main screening did not reveal any specific selection biases 5. The level of industrial and traffic pollution is very low in Nord-Trøndelag County, Norway, the population is homogenous, and the combination of questionnaires and interviews secured high-quality data for the explored risk factors. Nevertheless, the authors fully realise the limitations of the cross-sectional design, and therefore report presence of associations and not causal relationships.
Tobacco smoking and lung function
Tobacco smoking has a noxious effect on the airways. Inthis study, a strong,
dose-dependent association between tobacco smoking and reduced FEV1, FVC and FEV1/FVC was found in both sexes. This is
in agreement with the results from a meta-analysis of eight large US population-based
studies 6 and a longitudinal
study from Netherlands 13. But,
other cross-sectional studies, such as the Beijing respiratory health
study 2, a Canadian study 14, the French Cooperative study 8, the Tucson Airways study 15 and both a cross-sectional and longitudinal
study from Copenhagen 4, 16 have reported a greater decline in lung
function among females than males, associated with tobacco smoking. On theother
hand, opposite results have been found in both cross-sectional and longitudinal
studies, such as the Six Cities study 17, the Tucson Airways Study 18, the cross-sectional part of the Netherlands study 13, the Copenhagen study (after redefining
exclusion criteria, but not adjusting for quantity smoked) 19, an Italian study 20 and the UCLA study from Los Angeles 21. Comparisons between cross-sectional
and longitudinal studies are distorted, as those with better lung function
are more likely to continue in longitudinal studies 13.
The healthy-smoker effect (i.e. without respiratory symptoms) and different smoking prevalence could partly explain the divergent results found in previous studies, when never-smokers are used as reference groups. Xu et al. 22 showed that in the studies reporting greater smoking effects on lung function in females than in males, there was a relatively lowprevalence of male never-smokers (11–25%), whilst the opposite results were found in studies with higher prevalence of male never-smokers (27–43%). Given that "unhealthy" subjects (i.e. with respiratory symptoms) are a constant proportion of the population, and because such subjects with respiratory and cardiovascular diseases have a lower tendency to start or continue smoking compared with healthy subjects, the proportion of these in a never-smoking reference group would be higher in populations with a low prevalence of never-smokers. Any smoke-related difference between smokers and never-smokers would then be diluted. The present study, with a prevalence of never-smokers of 38.3% in males and 49.7% in females, is probably not prone to such prevalence effects.
Different sex effects of tobacco smoking could also be influenced by the fact that female never-smokers were older than female smokers, in contrast to that was found in males, but adjustments for age should take account of this.
Tobacco smoking and respiratory symptoms
The authors have previously reported that adjusted for age and smoking
burden, more females than males reported respiratory symptoms, such as wheezing,
breathlessness and cough without phlegm 5. In the present study, similar sex associations independent
of lung function were found, and significant higher FEV1 %
pred in females compared with males aged >60 yrs in asymptomatic
and symptomatic subjects, independent of doctor-diagnosed lung disease
or not. Even if tobacco smoking in females was associated with greater percentage
reduction in FEV1, FVC, and FEF25–75 compared
with males, this does not fully explain the discrepancy in symptom reporting
related to smoking burden between sexes. There are many different contributory
factors to this. First, females might be more aware of illness and diseases
than males. Assuming that FEV1 and FVC reflected all deleterious
effects of tobacco smoking in the airways, the present results of a higher
prevalence of symptom reporting infemales compared with males at similar levels
of lung function, would have supported such an explanation. However, conflicting
results on this issue have been reported. Macintyre et al. 23 did not find any sex
differences in the reporting of conditions, including trivial and mental conditions.
Further, Gijsbers et al. 24 found that even if females, when compared with males, reported
more physical symptoms, they reported similar illness behaviour. In addition,
different work exposure rather than different vulnerability has been found
to explain sex differences in health 25.
Secondly, there could be a selection bias among current smokers if symptomatic males succeeded in smoking cessation more often than symptomatic females. In the present population, males reported smoking cessation more frequently than females, regardless of reporting respiratory symptoms 5. However, even if analyses revealed a lower OR for respiratory symptoms by number of pack-yrs when the analyses were restricted to never-smokers/exsmokers compared with never-smokers/current smokers, similar difference with sex in reporting symptom by pack-yr was found (data not shown).
Thirdly, respiratory symptoms might be more strongly associated with global health and less specific for lung diseases in females compared with males 8. The authors' assessed global health by using a SRH measure with four steps, as this had been used previously in Norwegian population-based studies 9. Generally, the differences between SRH measures are marginal, females' rate poorer or similar to males, and in both sexes SRH measurements are found to be powerful predictors of future morbidity and mortality 26. In the present study, the association between respiratory symptoms and SRH was independent of sex, indicating a similar influence of respiratory symptoms on quality of life in males and females, independent of objective measurements, such as flow volume spirometry. Higher risk for reporting SRH "not very well" by pack-yr among females than among males is consistent with sex difference in association between pack-yrs and respiratory symptoms.
Fourthly, sex differences in symptoms could be due to differences in airway diameter. As the resistance to flow in a tube is inversely proportional to the fourth power of its radius, a similar reduction in radius in a small and large tube would influence the flow most in the former. In the present study, when including FEV1 % pred and thus taking different airway calibre into account, the sex difference in respiratory symptoms was still present, as also found by Leynaert et al. 3.
Fifthly, symptoms could be a more sensitive parameter of vulnerability in the peripheral airways, compared with FEV1 and FVC, reflecting changes mainly in the larger airways. There are differences in airway calibre and lung size between males and females of the same size, and this might influence the deposition of tobacco-smoke products 27. Females with smaller airway diameter would thus theoretically be more vulnerable to noxious gases deposited in the peripheral airways. Experimental studies by Wagner et al. 28 on patients with mild asthma, showed a considerable increase in peripheral resistance, despite having a normal lung function measured as FEV1 and FVC. Wagner et al. 28 also showed a strong correlation between increase in peripheral resistance and degree of bronchial hyperresponsiveness to methacholine. Interestingly, studies have shown a higher smoke-related bronchial hyperresponsiveness in females compared with males 3 and lower cough threshold in females than males when they were exposed to cough stimuli (capsaicin) 29. Further measurements of bronchial hyperresponsiveness in population-based studies might clarify this. So far, these have been mainly direct provocation tests (methacholine and histamine), but results regarding sensitivity and specificity of studies of simpler, indirect tests (mannitol) are promising for inclusion of such tests in large-scale studies 30.
Sixthly, there could be sex differences in validity of self-reported smoking behaviour and of inhalation pattern and exposure for passive smoking. Both estimation of pack-yrs and smoking behaviour have been reported to be fairly accurate in most studies 31, 32. The authors do not have data on whether there are different inhalation patterns between sexes. Due to a higher prevalence of smokers and smoking burden in males compared with females, both smoking and nonsmoking females have probably been exposed to more passive smoking than males, and this would dilute any deleterious effect of tobacco smoking in females compared with males. However, including passive smoking in the analyses did not influence the results in the present study.
To conclude, smoking burden was associated with similar absolute reduction in expiratory lung function measures in males and females, meaning that females had larger relative reductions in lung function. However, adjusted for age and pack-yrs, more females than males reported respiratory symptoms and the category "not very well" on self-rated health, adjusted for lung function. The associations between respiratory symptoms and self-rated health were independent of sex. This might support the hypotheses that females have greater perceived vulnerability for the deleterious effect of tobacco smoking than males. Whether this increased perception of symptoms are reflecting unmeasured pathological changes in the peripheral airways in addition to changes reflected by lung function measurements such as forced expiratory volume in one second or forced vital capacity, cannot be answered in this study. Use of more sophisticated lung function measurements and/or prospective follow-up of those with and without reported symptoms are possible ways of establishing whether symptom perception is a more sensitive tool indicating early deteriorating changes in the lower airways.
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Acknowledgements |
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The Nord-Trøndelag Health Study (the HUNT study) is a collaboration between the HUNT Research Centre, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Verdal, the National Institute of Public Health, the National Health Screening Service of Norway, and Nord-Trøndelag County Council. The authors would like to thank D. Price for language and content review.
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 J. Hallberg, A. Dominicus, U. K. Eriksson, M. Gerhardsson de Verdier, N. L. Pedersen, M. Dahlback, U. Nihlen, T. Higenbottam, and M. Svartengren Interaction between Smoking and Genetic Factors in the Development of Chronic Bronchitis Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 486 - 490. [Abstract] [Full Text] [PDF]
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 P.-O. Bridevaux, J. Cornuz, J.-M. Gaspoz, B. Burnand, U. Ackermann-Liebrich, C. Schindler, P. Leuenberger, T. Rochat, M. W. Gerbase, and for the SAPALDIA Team Secondhand Smoke and Health-Related Quality of Life in Never Smokers: Results From the SAPALDIA Cohort Study 2 Arch Intern Med, December 10, 2007; 167(22): 2516 - 2523. [Abstract] [Full Text] [PDF]
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 H. Kan, G. Heiss, K. M Rose, E. Whitsel, F. Lurmann, and S. J London Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study Thorax, October 1, 2007; 62(10): 873 - 879. [Abstract] [Full Text] [PDF]
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F. J. Martinez, J. L. Curtis, F. Sciurba, J. Mumford, N. D. Giardino, G. Weinmann, E. Kazerooni, S. Murray, G. J. Criner, D. D. Sin, et al. Sex Differences in Severe Pulmonary Emphysema Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 243 - 252. [Abstract] [Full Text] [PDF]
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M. B. Lund, J. Kongerud, W. Nystad, J. Boe, and J. R. Harris Genetic and environmental effects on exhaled nitric oxide and airway responsiveness in a population-based sample of twins Eur. Respir. J., February 1, 2007; 29(2): 292 - 298. [Abstract] [Full Text] [PDF]
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S. Sorhaug, A. Langhammer, H. L. Waldum, K. Hveem, and S. Steinshamn Increased serum levels of chromogranin A in male smokers with airway obstruction Eur. Respir. J., September 1, 2006; 28(3): 542 - 548. [Abstract] [Full Text] [PDF]
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 T. H. March, J. A. Wilder, D. C. Esparza, P. Y. Cossey, L. F. Blair, L. K. Herrera, J. D. McDonald, M. J. Campen, J. L. Mauderly, and J. Seagrave Modulators of Cigarette Smoke-Induced Pulmonary Emphysema in A/J Mice Toxicol. Sci., August 1, 2006; 92(2): 545 - 559. [Abstract] [Full Text] [PDF]
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 N. Chavannes, M. Huibers, T. Schermer, A Hendriks, C van Weel, E. Wouters, and C. van Schayck Associations of depressive symptoms with gender, body mass index and dyspnea in primary care COPD patients Fam. Pract., December 1, 2005; 22(6): 604 - 607. [Abstract] [Full Text] [PDF]
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H. M. Boezen, J. M. Vonk, S. C. van der Zee, J. Gerritsen, G. Hoek, B. Brunekreef, J. P. Schouten, and D. S. Postma Susceptibility to air pollution in elderly males and females Eur. Respir. J., June 1, 2005; 25(6): 1018 - 1024. [Abstract] [Full Text] [PDF]
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A. Lindberg, A.-C. Jonsson, E. Ronmark, R. Lundgren, L.-G. Larsson, and B. Lundback Ten-Year Cumulative Incidence of COPD and Risk Factors for Incident Disease in a Symptomatic Cohort Chest, May 1, 2005; 127(5): 1544 - 1552. [Abstract] [Full Text] [PDF]
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