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Copyright ©ERS Journals Ltd 2001
doi: 10.1183/09031936.01.00209301
Controlled, prospective trial of psychosocial function before and after continuous positive airway pressure therapy
1 Dept of Psychological Medicine, University of Glasgow, and 2 Edinburgh Sleep Centre, Dept of Medicine, University of Edinburgh, Edinburgh, UK
CORRESPONDENCE: H.M. Engleman, Edinburgh Sleep Centre (Ward 48), Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK. Fax: 44 1315362362
Keywords: Marital satisfaction, positive pressure therapy, quality of life, sleep apnoea syndromes, sleepiness
Received: January 29, 2001
Accepted July 10, 2001
H.M. Engleman was supported by a fellowship from the British Lung Foundation.
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Abstract |
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The aim of the study was to investigate psychosocial function before and after continuous positive airway pressure (CPAP) therapy, and establish the determinants and consequences of objective CPAP use.
In a prospective, parallel-group study, changes in psychosocial scores were compared with conservative management or CPAP therapy for the sleep apnoea/hypopnoea syndrome (SAHS). Patient/partner couples from the top (CPAP treated, n=44) or bottom (conservatively treated, n=25) of a CPAP waiting list rated marital satisfaction (evaluation and nurturing relationship issues, communication and happiness (ENRICH), behavioural questionnaire), health/functional status (Short-Form-36 Health Survey, functional outcomes of sleep questionnaire) and sleepiness (Epworth sleepiness scale). Both groups' ratings at baseline were completed while on conservative therapy.
Baseline variables did not differ between groups. At follow-up, all seven summary psychosocial scores were statistically better in CPAP-treated patients, effect sizes (ES) ranging from moderate (0.5 sd: marital satisfaction) to very large (>1.0 sd: patients health, functional status and sleepiness scores). Scores in conservatively-treated patients deteriorated to a small or moderate degree (ES –0.2– –0.7 sd), while those in the CPAP-treated group improved to a larger degree (0.3–1.3 sd). Baseline polysomnographical and psychosocial scores, including marital satisfaction, did not predict objective CPAP use (r<0.3). CPAP use was modestly correlated (r=0.3–0.6) with improvement in all psychosocial areas.
Continuous positive airway pressure produced statistically and clinically significant psychosocial improvements, some of large magnitude, in psychosocial function. Determinants of usage were not identified, but benefits and usage were positively correlated.
Symptoms of the sleep apnoea/hypopnoea syndrome (SAHS) impact on many aspects of the daily behaviour and function of a patient, affecting marital and family relationships 1–3, work efficiency and income 1, 4, activity level 4–7 and general health and functional status 5, 8–17. Controlled, prospective clinical trials employing validated psychosocial outcomes 12–17 have documented improvements in sleepiness and general health/functional status after continuous positive airway pressure (CPAP) therapy, but there have been no prospective controlled trials of changes in marital satisfaction. Quantitative comparisons of the magnitude of therapeutic effects across these related psychosocial areas are scanty.
A prospective, controlled, parallel-arm study of psychosocial function after CPAP therapy, incorporating validated outcome measurements of marital satisfaction, general health/functional status and sleepiness was therefore conducted. The primary aims of the study were to compare changes in psychosocial function in CPAP-treated patients with those in conservatively-treated patients, and to compare the magnitudes of therapeutic effects across psychosocial outcome measures. Secondary aims were to seek putative determinants of CPAP use from baseline demographic, polysomnographic and psychosocial scores, and putative consequences of CPAP use in psychosocial therapeutic benefits.
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Method |
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TOPAbstractMethodResultsDiscussionAcknowledgementsReferences |
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Trial design
This trial was a repeated measures, parallel-arm, intention-to-treat study of conservative versus CPAP treatment in a clinical setting. Psychosocial questionnaires were mailed to patient/partner couples at baseline, when all patients were being managed conservatively with advice on weight loss, sleeping posture and avoidance of evening alcohol. "Conservative" patients were still receiving conservative management only when followed-up 3 months later. "CPAP" couples were followed-up 3 months after the patients' CPAP titration. Both subject groups were posted questionnaires on an intention-to-treat basis. The protocol was approved by the local ethics subcommittee, and written consent obtained from patients and their partners.
Study participants
Entry criteria for all patients were the clinical recommendation of CPAP, and cohabitation with a partner. A diary of CPAP-titration bookings provided the sampling pool, with questionnaire mailings to all eligible couples. Position on the waiting list acted as the group selection criterion. Couples booked for CPAP titration in 5–6 months were assigned to "conservative" follow-up, 3 months later. Those with a <3-month wait were assigned to "CPAP" follow-up, 3 months after titration.
Eligibility criteria were met by 142 patient/partner couples (CPAP: n=97, conservative: n=45), who were posted the study questionnaires with a request to participate in a study of symptoms in SAHS. Of these, 62 (44 CPAP, 18 conservative) were not included. A total of 27, failed to return a valid consent form, 18 declined to participate, and 17 did not respond at baseline. A further 11 couples (9 CPAP, 2 conservative) failed to respond at follow-up, resulting in final sample sizes of 44 CPAP patients and 25 conservative patients. Demographic features of participating patients (n=69, 23% female; mean age±sd was 50±10 yrs and apnoea/hypopnoea index (AHI) 43±33·h–1) were not different from those of all CPAP-recommended patients at the Edinburgh Sleep Centre (n=389. 18% female, mean age 51±12 yrs and AHI 44±39·h–1; all p>0.5).
Outcome measurements
Questionnaires of marital satisfaction were completed by patients and partners, and those of health and functional status and sleepiness by patients only.
Marital satisfaction
Evaluation and nurturing relationship issues, communication and happiness marital satisfaction scale
The evaluation and nurturing relationship issues, communication and happiness (ENRICH) marital satisfaction (EMS) scale 18 is a 15-item questionnaire providing a marital satisfaction score, corrected for idealistic distortion, for both partners in a marital relationship. Corrected scores are presented as normative percentile values 18.
Behavioural questionnaire
An in-house behavioural questionnaire asked subjects the frequency of bed-sharing, the number of cuddles/hugs shared, and the number of disagreements or arguments within the past week.
Health/functional status
Short Form-36 health survey
The Short Form-36 (SF-36) questionnaire 19 is a generic 36-item measure of subjective health status, providing three summary scores for health transition, physical and mental components. The score range for health transition is 1–5, and standardization provides population means±sd of 50±10 for physical and mental component scores. The eight subscores (physical function, role-physical, role-emotional, bodily pain, social function, mental health, vitality and general health) range from 0–100.
Functional outcomes of sleep questionnaire
The functional outcomes of sleep questionnaire (FOSQ) 5 provides a rating of sleepiness-related functional impairment, sensitive to impairment in sleep disorders. The FOSQ was administered in an abridged 26-item version (excluding the sexual activities subscale), with a total score range of 0–16. Subscores for the general productivity, social outcomes, activity level and vigilance scales each have a range of 0–4. The sexual activities subscale was not administered lest this particular middle-aged Scottish population found its content too intrusive, and withdrew participation.
Sleepiness
Epworth sleepiness scale
The eight-item Epworth scale is a retrospective "trait" rating, widely used in clinical practice, of the likelihood of dozing in situations of different soporificity 7. It has a total score range of 0–24 and a normative mean±sd of 5±3 20.
Objective continuous positive airway pressure use
CPAP-use in patients were calculated from readings of the "on-time" counters of home CPAP units. These were obtained at the routine 3-month clinic follow-up or by telephone enquiry to patients. Total hours of use were divided by the number of days since issue, to produce an average daily running time for the units.
Analysis
Primary outcome variables (table 1
) were the summary scores from the validated instruments (couples' marital satisfaction scores and patients' SF-36 health transition, physical component and mental component scores, FOSQ total and Epworth score). Variables of secondary interest (table 2) were also analysed to further elucidate group differences. These were unvalidated or subscore outcomes (couples' in-house behavioural ratings, and patients' SF-36 and FOSQ subscores).
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The statistical significance of score differences between the treatment groups was assessed using the Mann-Whitney U-test, and within-group changes using Wilcoxons test. Clinical significance was evaluated by computing effect sizes (ES) (score difference/score sd) 21, to standardize and quantify therapeutic differences in psychosocial scores. The conservative groups' baseline sd was used as the common denominator for ES calculations, as appropriate for parallel-limb trials 16, 22. ES were conventionally interpreted as representing clinically small (0.25 sd units), moderate (0.50 sd) or large (0.75 sd) differences 21.
Two-tailed Spearman correlational analyses sought determinants of CPAP use from baseline demographical, polysomnographical and psychosocial variables. These were also used to seek putative psychosocial consequences of CPAP use.
All analyses were performed using SPSS for Windows, with alpha-significance values set at 0.05. Prospective calculation showed the sample sizes provided 90% power to show "large" differences of 0.8 sd between treatment groups (unequal groups; n=69), and 90% power to show "moderate" r-values of 
0.5 within the CPAP group (n=44).
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Results |
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TOPAbstractMethodResultsDiscussionAcknowledgementsReferences |
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Between-group comparison at baseline
Patients in conservative and CPAP groups did not differ in baseline demographic features or polysomnographic severity (table 3
). None of the primary or secondary psychosocial scores, including Epworth sleepiness score, were different between groups at baseline.
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Between-group comparison at follow-up
Primary outcomes
All seven primary psychosocial variables (table 1
and fig. 1) showed significantly better psychosocial function at follow-up in the CPAP than in the conservative group. ES for these ranged from the moderate to large, from 0.5–2.2 sd units.
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: conservatives; 
: continuous positive airway pressure. p<0.05 for all within-group changes, except for the continuous positive airway pressure of the partner. p<0.05 for all between-group differences.ES for marital satisfaction scores were the smallest observed, but these suggested improvement of moderate or large size to the ratings of patients and partners, respectively. ES for summary scores of health/functional status and sleepiness all indicated large or very large between-group differences. The two largest between-group ES were produced from the single-item SF-36 health transition score and the FOSQ total score.
Secondary outcomes
Fourteen of 18 secondary outcome variables showed significantly better psychosocial function in the CPAP than in the conservative group, while none showed better function with conservative treatment (table 2). The only nonsignificant ES were patients' and partners' ratings for bed-sharing and embrace frequency.
All other psychosocial subscore ES showed advantages of at least moderate size with CPAP. Between-group ES were very large (>1 sd) for the frequency of marital disagreement, the SF-36 role-physical, role-emotional, mental health and vitality subscores and all FOSQ sleepiness subscores.
Within-subject changes
Primary outcomes
In conservatively-treated patients, all primary psychosocial variables showed significant deterioration of small to moderate ES (–0.2––0.7 sd) (table 1 and fig. 1). These decrements were of small size for physical component, Epworth and FOSQ summary scores, and of moderate size for ratings of marital satisfaction, health transition and mental component summary scores.
In the CPAP group, all summary scores except partners' marital satisfaction showed significant improvement. The ES for therapeutic improvement in patients' marital satisfaction (0.3 sd) was small, but the remaining five ES summary scores were large or very large (>1.0 sd: health transition, FOSQ and Epworth) in size.
Secondary outcomes
In conservatively treated patients, 12 of 18 secondary psychosocial outcomes worsened significantly at follow-up (ES –0.1––0.7 sd). Subscores that did not change significantly were couples bed-sharing and embrace frequency and patients' SF-36 social function and general health scores. Deterioration of small size was observed in SF-36 physical function, role physical, role emotional and pain, and in all FOSQ subscores. Moderately sized decrements were seen for couples disagreement frequencies and patients SF-36 vitality scores.
In the CPAP group, all bar two outcomes (couples embrace frequencies) improved significantly (ES 0.2–1.7 sd). Small ES were observed in couples' bedsharing and patients' SF-36 pain ratings, and ES of moderate size in couples' disagreement frequency and the majority of SF-36 subscores. Large and very large ES were seen for SF-36 role physical, general health and vitality subscore, and for all FOSQ subscores.
Objective continuous positive airway pressure use
Mean rate of CPAP use in the CPAP group was 4.4 (sd 2.1) h·night–1, with 25% of patients using it for 
3 h·night–1.
Putative determinants of continuous positive airway pressure use
Within the 44 patients receiving CPAP, no significant correlates of objective use were found amongst baseline age, AHI, or primary psychosocial summary scores (r<0.2, p>0.1). Associations between secondary psychosocial outcomes (behavioural FOSQ and SF-36 subscores) at baseline and subsequent CPAP use were also nonsignificant (r<0.28, p>0.06).
Putative consequences of continuous positive airway pressure use
CPAP use correlated significantly and in the expected direction with changes in five of the seven primary psychosocial scores, linking greater use with larger score improvement (table 4).
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Correlation coefficients for CPAP use and change in psychosocial function primary outcomes were all in the expected direction, explaining 10–32% of variance in these psychosocial score changes. Amongst these, partners' marital satisfaction was the weakest and FOSQ total the strongest correlate of subsequent CPAP use. Amongst secondary outcomes, significant correlates of objective CPAP use comprised: behavioural disagreement frequency (r=–0.4), all four FOSQ subscores (r=–0.5–0.6) and SF-36 subscores for vitality, social function and general health (r=0.3–5), these explaining 9–36% variance in CPAP use.
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Discussion |
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TOPAbstractMethodResultsDiscussionAcknowledgementsReferences |
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This prospective, controlled clinical trial used validated instruments to investigate psychosocial changes after CPAP or conservative therapy. Its findings corroborated those of previous controlled trials 11–17 of improved SF-36 and Epworth scores after CPAP, and showed for the first time in a controlled setting additional improvements in marital satisfaction 18 and sleepiness-related functional status 5.
The standardization of psychosocial scores as ES allowed the magnitude of therapeutic changes in these to be compared across treatments and across outcomes. Across treatments, summary scores reflecting marital satisfaction, health, functional status and sleepiness all favoured CPAP over conservative therapy. Score differences between treatments were of a size conventionally interpreted as representing a large clinical advantage for CPAP.
Across outcomes, marital satisfaction scores tended to improve less than health, functional status and sleepiness scores. Within-group ES segregated by treatment type, with broadly moderate decrements among the conservative group in all psychosocial summary scores, and broadly large improvements in the CPAP group, in all but marital satisfaction summary scores. The magnitude of differences in outcome ES may, in part, relate to whether these were assessed using generic or symptom-specific questionnaires. Generic questionnaires (ENRICH, SF-36) facilitate cross-disease comparisons 9, but they may be less sensitive than symptom-specific measures (FOSQ, Epworth). However, even generic primary outcomes (table 1) showed mostly "large" ES advantages with CPAP.
The correlational analyses explored potential psychosocial determinants and consequences of CPAP use. An association between partner influences and CPAP use had been suggested in a previous study 23. However, baseline ENRICH scores were not linked to adherence in this sample, nor were any other polysomnographic or psychosocial variables, although large-sample, long-term follow-up studies have suggested that the patients' disease 24, 25 and symptom 25 severity may partially determine acceptance of CPAP. Because adherence is behavioural and multifactorial, univariate correlations tend to be weak and below the threshold (r=0.5) for which the analysis was powered. The variability in findings from other studies of determinants of CPAP use, some observing suggestive relationships 26–28 and some, like this study, not 29, is compatible with such a profile.
However, like some previous correlational studies 4, 26–28, this investigation did suggest that increasing psychosocial benefits accrued with increasing CPAP use. These included greater benefit in partners' marital satisfaction and patients' general health, mental wellbeing, and sleepiness-related functional limitations. This provides grounds for targeting failing CPAP adherence for support and intervention wherever possible 23. However, further studies are required to assess other psychological contributants to the patients' decision-making on CPAP acceptance and adherence.
Methodological shortcomings of this treatment study included a lack of randomization and blinding, exclusion of FOSQ sexual function subscale and a participation rate limited to 47%. The treatment selection criterion replacing randomization was position on a CPAP titration list. This represented an accommodation of convenience to the demands of a clinical sleep service, but retrospectively appeared acceptably successful in yielding a demographically, polysomnographically and symptomatically homogeneous baseline population. This "smoothing" effect would be assisted by local practice of booking each diagnosed patient into the first available titration slot, so that position is determined by time since diagnosis more than disease severity. The deliberate omission of the FOSQ sexual function subscale reduced the sensitivity of this study to specific sexual aspects of psychosocial function. Further specialized sexual research in a suitable population could be of interest.
The lack of blinding in this study was a constraint imposed by clinical service restrictions, necessitating conservative management to bridge the waiting time until CPAP treatment could be provided. This may have resulted in differential demand characteristics in the treatment groups, with lower expectations of benefit on follow-up in conservatively managed patients than in those having received CPAP. Although this is a plausible explanation for at least some component of the moderately-sized psychosocial decrements seen in conservatively-treated patients, these could also reflect increasing symptomatology with objective disease deterioration over time 30.
The limited participation rate was typical of that for a postal study, but this also could have introduced sampling bias. However, more than one-third of nonparticipants were excluded as "responders" because of simple omission to identify themselves by signing the consent form. The response rate once adjusted for these is a more acceptable 66% of eligible participants. However, evidence of bias was not seen either in baseline comparisons between continuous positive airway pressure and conservatively-treated patients (table 1 and Results) or between the study sample and local continuous positive airway pressure patients (study participants).
Although this trial was compromised in some aspects by its accommodation within a local clinical pathway, its generalizability to the clinical setting was as a result enhanced. While blinded randomized-controlled trials are conducted in an experimental setting with treatments presented as equivalent, patients and practitioners in the clinical environment are increasingly well-informed of treatment choices, and they are frequently aware that resource restrictions limit access to treatments of choice. In this sample, the status of waiting for continuous positive airway pressure was associated with statistically and clinically significant deterioration in psychosocial scores of marital satisfaction, health and functional status and sleepiness. These quantitative outcomes, acquired in the clinical environment, could be incorporated as inputs to economic models of health service provision for sleep apnoea/hypopnoea syndrome 31, counterbalancing costs of quicker continuous positive airway pressure provision.
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Acknowledgements |
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The authors would like to thank the patients and administrative, technical, nursing, medical and research staff of the Edinburgh Sleep Centre.
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