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Eur Respir J 2001; 18:738
Copyright ©ERS Journals Ltd 2001

Course and prognosis of sarcoidosis in African-Americans versus Caucasians

M. Luisetti, A. Beretta and L. Casali

Clinica di Malattie dell'Apparato Respiratorio, IRCCS Policlinico San Matteo, Pavia, Italy

From the authors:

In response to the letter from Reich 1, we are far from believing that sarcoidosis mortality is higher in African-Americans than in Caucasians, since we stated that mortality rates are reported to be similar among races 2. We therefore agree with J.M. Reich's qualification that findings of higher age-adjusted mortality rates reported among African-Americans than among Caucasians in the USA 3 reflect those of sarcoidosis incidence 4. With reference to ethnic differences in disease severity, there is a general consensus from the review of large series that sarcoidosis in Blacks is more severe, and that Whites are more likely to present with asymptomatic disease 5. As an example, the paper of Gideon and Mannino 3 reported that mortality rate in African-Americans peaked about 2 decades earlier than in Caucasians (ages 45–54 versus 75–84 yrs). This finding is taken as a further support of the notion that sarcoidosis in African-Americans has an earlier onset and a more aggressive course 4.

References

  1. Reich JM. Course and prognosis of sarcoidosis in African-Americans versus Caucasians. Eur Respir J 2001;17:833.[Free Full Text]
  2. Luisetti M, Beretta A, Casali L. Genetic aspects in sarcoidosis. Eur Respir J 2000;16:768–780.[Abstract]
  3. Gideon NM, Mannino DM. Sarcoidosis mortality in the United States, 1979–1991. Am J Med 1996;100:423–427.[CrossRef][ISI][Medline] [Order article via Infotrieve]
  4. Rybicki BA, Maliarik MJ, Major M, Popovich J Jr, Iannuzzi MC. Epidemiology, demographics, and genetics of sarcoidosis. Sem Respir Infect 1998;3:166–173.
  5. Hunninghake GW, Costabel U, Ando M, et al. ATS/ERS/WASOG statement in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999;16:149–173.[ISI][Medline] [Order article via Infotrieve]




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