Aluminium potroom asthma: the Norwegian experience

Work-related asthma in aluminium potroom workers, is reviewed and discussed, mainly on the basis of own investigations. The occurrence of work-related asthma has been shown to be associated with the duration of potroom employment, although the prevalence of asthmatic symptoms is not significantly different from that of the general population. Typical manifestations of occupational asthma are described in potroom workers, and a close relationship between the levels of fluoride exposure and work-related asthmatic symptoms has been observed. The existence of occupational asthma in aluminium potroom workers has been confirmed by characteristic patterns of repeated peak flow measurements, supported by changes in methacholine responsiveness in workers with suspected work-related asthma. However, no immunological test is available to establish the diagnosis. Methacholine challenge appears to be inappropriate for screening aluminium potroom workers in order to detect work-related asthma. Current smoking, but not self-reported allergy, is a risk factor for potroom asthma. A family history of asthma and previous occupational exposure may have some effect on the risk of developing symptoms. The prognosis of potroom asthma seems to depend on early replacement to unexposed work. The pathogenetic mechanisms are unknown, although some studies indirectly imply a hypersensitivity reaction. Future studies involving specific bronchial challenge appear to be necessary to find the causal agent(s) of aluminium potroom asthma.

This article has been cited by other articles:

				J. Cui, N. de Klerk, M. Abramson, A. Del Monaco, G. Benke, M. Dennekamp, A. W. Musk, and M. Sim Fractional Polynomials and Model Selection in Generalized Estimating Equations Analysis, With an Application to a Longitudinal Epidemiologic Study in Australia Am. J. Epidemiol., January 1, 2009; 169(1): 113 - 121. [Abstract] [Full Text] [PDF]

				T. Sjaheim, J. Kongerud, O. Bjortuft, P. A. Drablos, D. Malterud, and T. S. Halstensen Reduced bronchial CD4+ T-cell density in smokers with occupational asthma Eur. Respir. J., December 1, 2006; 28(6): 1138 - 1144. [Abstract] [Full Text] [PDF]

				G L Delclos, A A Arif, L Aday, A Carson, D Lai, C Lusk, T Stock, E Symanski, L W Whitehead, F G Benavides, et al. Validation of an asthma questionnaire for use in healthcare workers. Occup. Environ. Med., March 1, 2006; 63(3): 173 - 179. [Abstract] [Full Text] [PDF]

				C. E. Mapp, P. Boschetto, P. Maestrelli, and L. M. Fabbri Occupational Asthma Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 280 - 305. [Abstract] [Full Text] [PDF]

				O. Vandenplas and J-L. Malo Definitions and types of work-related asthma: a nosological approach Eur. Respir. J., April 1, 2003; 21(4): 706 - 712. [Abstract] [Full Text] [PDF]

				D. Lieberman, D. Lieberman, S. Printz, M. Ben-Yaakov, Z. Lazarovich, B. Ohana, M. G. Friedman, B. Dvoskin, M. Leinonen, and I. Boldur Atypical Pathogen Infection in Adults with Acute Exacerbation of Bronchial Asthma Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 406 - 410. [Abstract] [Full Text] [PDF]

				M B Lund, P I Øksne, R Hamre, and J Kongerud Increased nitric oxide in exhaled air: an early marker of asthma in non-smoking aluminium potroom workers? Occup. Environ. Med., April 1, 2000; 57(4): 274 - 278. [Abstract] [Full Text]