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This Article Full Text Full Text (PDF) All Versions of this Article: 34/5/1148    most recent 09031936.00041009v1 Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Vardakas, K. Z. Articles by Falagas, M. E. PubMed PubMed Citation Articles by Vardakas, K. Z. Articles by Falagas, M. E.

Incidence, characteristics and outcomes of patients with severe community acquired-MRSA pneumonia

¹ Alfa Institute of Biomedical Sciences (AIBS), Athens, ² Dept of Medicine, "G. Gennimatas" General Hospital, Thessaloniki, Greece, and ³ Dept of Medicine, Tufts University School of Medicine, Boston, MA, USA.

CORRESPONDENCE: M. E. Falagas, Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Greece. E-mail: m.falagas{at}aibs.gr

Keywords: Pneumonia, resistance, Staphylococcus aureus

Received: March 12, 2009
Accepted June 5, 2009

We evaluated the published data for the incidence, characteristics and outcomes of patients with community-acquired pneumonia (CAP) due to methicillin-resistant Staphylococcus aureus (MRSA). The estimated incidence of MRSA CAP is 0.51–0.64 cases per 100,000.

We identified 74 articles reporting data on 114 patients. Influenza like symptoms was reported in 41% of patients. Pneumonia improved in 59 (54.1%) out of 109 patients; 49 (44.5%) out of 110 patients died. The duration of hospitalisation was 38.1±24.9 and 8.3±11.7 days, respectively. The duration of intensive care unit (ICU) stay was 18.9±13.6 and 6.8±9.7 days, respectively. 76 strains carried the Panton–Valentine leukocidin gene.

The univariate analysis showed that multi-organ failure (p<0.001), leukopenia (p<0.001), admission to ICU (p<0.001), mechanical ventilation (p<0.001), use of aminoglycosides after culture results (p<0.001), shock (p = 0.001), acute respiratory distress syndrome (p = 0.001), influenza like symptoms (p = 0.008), disseminated intravascular coagulation (p = 0.042) and rash (p = 0.04) were the factors associated with death.

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				A. Nakou, M. Woodhead, and A. Torres MRSA as a cause of community-acquired pneumonia Eur. Respir. J., November 1, 2009; 34(5): 1013 - 1014. [Full Text] [PDF]