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Mortality in bronchiectasis: a long-term study assessing the factors influencing survival

¹ Host Defence Unit, ² Interstitial Lung Disease Dept, and ³ Radiology Dept, Royal Brompton Hospital, London, UK.

CORRESPONDENCE: R. Wilson, Host Defence Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK. E-mail: r.wilson{at}rbht.nhs.uk

Keywords: Bronchiectasis, mortality, prognosis

Received: January 8, 2009
Accepted March 31, 2009

There is little literature about the mortality associated with bronchiectasis. The aim of the present study was to investigate factors affecting mortality in patients with bronchiectasis.

In total, 91 patients were examined for aetiology, pulmonary function tests, high-resolution computed tomography, sputum microbiology and quality of life scores and were then followed over 13 yrs.

Overall, 29.7% of the patients died. On multivariate analysis, age, St George’s Respiratory Questionnaire activity score, Pseudomonas aeruginosa infection, total lung capacity (TLC), residual volume/TLC and the transfer factor coefficient were all independently associated with mortality.

In patients with moderate to severe bronchiectasis, mortality is associated with a degree of restrictive and obstructive disease, poor gas transfer and chronic pseudomonas infection. These features should guide future research into disease progression, and identify those patients needing intensive treatment.