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Published online before print November 14, 2008, 10.1183/09031936.00123608
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Eur Respir J 2009; 33:551-558
Copyright ©ERS Journals Ltd 2009

Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy

T. Müller1, M. Lubnow1, A. Philipp2, T. Bein3, A. Jeron1, A. Luchner1, L. Rupprecht2, M. Reng4, J. Langgartner4, C. E. Wrede4, M. Zimmermann3, D. Birnbaum2, C. Schmid2, G. A. J. Riegger1 and M. Pfeifer1

1 Dept of Internal Medicine II, 2 Dept of Cardiothoracic Surgery, 3 Dept of Anaesthesiology, and 4 Dept of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany.

CORRESPONDENCE: T. Müller, Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany. Fax: 49 9419447282. E-mail: thomas.mueller{at}klinik.uni-regensburg.de

Keywords: Acute respiratory distress syndrome, extracorporeal carbon dioxide removal, interventional lung assist, oxygen transfer

Received: August 11, 2008
Accepted September 27, 2008

Respiratory acidosis can become a serious problem during protective ventilation of severe lung failure. A pumpless arteriovenous interventional lung assist (iLA) for extracorporeal carbon dioxide removal has been used increasingly to control critical respiratory situations. The present study sought to evaluate the factors determining the efficacy of iLA and calculate its contribution to gas exchange.

In a cohort of 96 patients with severe acute respiratory distress syndrome, haemodynamic parameters, oxygen consumption and carbon dioxide production as well as gas transfer through the iLA were analysed.

The measurements demonstrated a significant dependency of blood flow via the iLA device on cannula size (mean±SD 1.59±0.52 L·min–1 for 15 French (Fr), 1.94±0.35 L·min–1 for 17 Fr, and 2.22 ±0.45 L·min–1 for 19 Fr) and on mean arterial pressure. Oxygen transfer capacity averaged 41.7±20.8 mL·min–1, carbon dioxide removal was 148.0±63.4 mL·min–1. Within two hours of iLA treatment, arterial oxygen partial pressure/inspired oxygen fraction ratio increased significantly and a fast improvement in arterial carbon dioxide partial pressure and pH was observed.

Interventional lung assist eliminates ~50% of calculated total carbon dioxide production with rapid normalisation of respiratory acidosis. Despite limited contribution to oxygen transfer it may allow a more protective ventilation in severe respiratory failure.




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