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Eur Respir J 2009; 33:419-425
Copyright ©ERS Journals Ltd 2009

Some principles and practices of genetic biobanking studies

A. K. MacLeod1, D. C. M. Liewald1, M. M. McGilchrist2, A. D. Morris2, S. M. Kerr1 and D. J. Porteous1,3

1 Medical Genetics Section, Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, 2 Health Informatics Centre, University of Dundee, Ninewells Hospital, Dundee, UK, 3 on behalf of Generation Scotland; for details of the Generation Scotland Scientific Committee, please see the Acknowledgements section.

CORRESPONDENCE: A. K. MacLeod, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK, Fax: 44 1316511059. E-mail: andrew.macleod{at}ed.ac.uk

Keywords: Biobanking, data acquisition, data coding, laboratory information management system, statistical genetics

Received: March 20, 2008
Accepted October 15, 2008

Genetic biobanking studies are becoming increasingly common as researchers recognise the need for large samples to identify the genetic basis of susceptibility to complex disease. In the present review, the authors give a brief overview of some of the issues that should be considered when implementing such a large-scale project, from study design to sample management, data coding and storage to the statistical analysis and engagement with the public. Specific solutions to these issues are presented, as implemented in the Generation Scotland projects, but the general principles outlined are relevant to any biobanking study.






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