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Effects of curcumin or dexamethasone on lung ischaemia–reperfusion injury in rats

¹ Dept of Pulmonary Medicine, Zhongshan Hospital, Fudan University, and ² Dept of Pathology, Fudan University, Shanghai, China.

CORRESPONDENCE: C. Bai, Dept of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China. Fax: 86 2154961729. E-mail: bai.chunxue{at}zs-hospital.sh.cn

Keywords: Curcumin, ischaemia–reperfusion, lung, microvascular permeability, nuclear factor-B, oxidative stress

Received: October 28, 2007
Accepted August 29, 2008

The present study aimed to investigate potential effects of curcumin (CUR) and dexamethasone (DXM) on ischaemia–reperfusion (I/R) induced lung injury in rats.

Experimental rats were pre-treated with a single i.p. dose of vehicle, CUR (50 mg·kg^–1 or 200 mg·kg^–1) or DXM (5 mg·kg^–1), 2 h before anaesthesia and subjected to left lung hilus clamping with 90-min ischaemia followed by 4 h of reperfusion.

Pre-treatment with CUR (200 mg·kg^–1) or DXM markedly attenuated I/R-induced barrier disruption, lung oedema, tissue inflammation, hypoxaemia 4 h after reperfusion, and overactivation of nuclear factor-B, inflammatory cytokines, myeloperoxidase and malondialdehyde.

It appears that curcumin attenuates acute lung injury, probably through improving oxidative stress and inhibiting nuclear factor-B-mediated expression of inflammatory cytokines. Thus, curcumin may be an alternative therapy for improving the outcomes of ischaemia–reperfusion-induced lung injury.