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The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function

¹ Respiratory Research Unit and Depts of ² Medical and Surgical Sciences and ³ Preventive and Social Medicine, Dunedin School of Medicine, and ⁴ School of Physiotherapy, University of Otago, Dunedin, New Zealand.

CORRESPONDENCE: D. R. Taylor, Otago Respiratory Research Unit, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, New Zealand. Fax: 64 34776246. E-mail: robin.taylor{at}stonebow.otago.ac.nz

Keywords: Lung function, obesity, physiology, X-ray absorptiometry

Received: August 27, 2007
Accepted February 28, 2008

Respiratory function is impaired in obesity but there are limitations with body mass index and skin-fold thickness in assessing this effect. The present authors hypothesised that the regional distribution of body fat and lean mass, as measured by dual-energy X-ray absorptiometry (DXA), might be more informative than conventional measurements of total body fat.

In total, 107 subjects (55 female, 51.4%) aged 20–50 yrs with no respiratory disease were recruited. Respiratory function tests, anthropometric measurements and a DXA scan were performed. Partial correlation and linear regression analyses were used to explore the effect of adiposity and lean body mass on respiratory function.

The majority of respiratory function parameters were significantly correlated with DXA and non-DXA measurements of body fat. Neither thoracic nor abdominal fat had a greater effect. There were some differences in the effect of adiposity between the sexes. Respiratory function was negatively associated with lean body mass in females but positively associated in males. This disappeared after adjustment in females but remained in males.

The effects of thoracic and abdominal body fat on respiratory function are comparable but cannot be separated from one another.

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