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Mycobacterium avium complex disease: prognostic implication of high-resolution computed tomography findings

¹ Second Division, Dept of Internal Medicine, Hamamatsu University School of Medicine, ² Dept of Respiratory Medicine, National Hospital Organization Tenryu Hospital, ³ Dept of Respiratory Medicine, Seirei Mikatahara General Hospital, and ⁴ Dept of Respiratory Medicine, Iwata Municipal Hospital, Shizuoka, Japan.

CORRESPONDENCE: Y. Nakamura, Second Division, Dept of Internal Medicine, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan. Fax: 81 534352354. E-mail: nakayuta{at}hama-med.ac.jp

Keywords: High-resolution computed tomography, Mycobacterium avium complex, nontuberculous Mycobacterium, prognosis, sputum conversion

Received: June 20, 2007
Accepted February 19, 2008

To evaluate the prognostic implications of computed tomography (CT) findings in assessing responses to treatment in Mycobacterium avium complex (MAC) pulmonary disease without underlying lung disease, high-resolution (HR)CT findings were correlated based on the results of sputum conversion after anti-MAC therapy.

A total of 59 patients underwent HRCT before treatment and the therapeutic efficacy was evaluated by the results of sputum conversion.

Atelectasis, cavities and pleural thickening on HRCT were significantly more frequent and extensive among patients in the sputum nonconverted group than among those in the converted group. Furthermore, bronchiectasis was also significantly more extensive among patients in the nonconverted group, even though there was no significant difference in frequency between these two groups.

These results suggest that high-resolution computed tomography findings are good predictors of response to treatment in Mycobacterium avium complex pulmonary disease.

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				D. Aggarwal and P.R. Mohapatra High-resolution computed tomography in Mycobacterium avium complex disease: one step forward, two steps back Eur. Respir. J., September 1, 2008; 32(3): 813 - 813. [Full Text] [PDF]