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European reference equations for CO and NO lung transfer

¹ Hylab, Laboratory of Clinical Physiology and Exercise at Groupe Hospitalier Mutualiste, Grenoble, ³ Lung Testing Dept, Bordeaux University Hospital, ² Dept of Physiology, and ⁴ Bordeaux Mathematics Institute, University of Bordeaux 2, Bordeaux, France.

CORRESPONDENCE: H. Guénard, Service EFR, Hôpital du Haut Lévêque, 33604 Pessac, France. Fax: 33 557656036. E-mail: herve.guenard{at}chu-bordeaux.fr

Keywords: Ageing, capillary lung volume, carbon monoxide, diffusion, nitric oxide, pollution

Received: May 24, 2007
Accepted January 7, 2008

The aim of the present study was to calculate reference equations for carbon monoxide and nitric oxide transfer, measured in two distinct populations.

The transfer factor of the lung for nitric oxide (T_L,NO) and carbon monoxide (T_L,CO) were measured in 303 people aged 18–94 yrs. Measurements were similarly made in two distant cities, using the single-breath technique. Capillary lung volume (V_c) and membrane conductance, the diffusing capacity of the membrane (D_m), for carbon monoxide (D_m,CO) were derived.

The transfer of both gases appeared to depend upon age, height, sex and localisation. The rate of decrease in both transfers increased after the age of 59 yrs. T_L,NO/alveolar volume (V_A) and T_L,CO/V_A were only age-dependent. The mean T_L,NO/T_L,CO was 4.75 and the mean D_m/V_c was 6.17 min^–1·kPa^–1; these parameters were independent of any covariate. V_c and D_m,CO calculations depend upon the choice of coefficients included in the Roughton–Forster equation. Values of 1.97 for D_m,NO/D_m,CO ratio and 12.86 min·kPa^–1 for 1/red cell CO conductance are recommended.

The scatter of transfer reference values in the literature, including the current study, is wide. The present results suggest that differences might be due to the populations themselves and not the methods alone.