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Outcomes for COPD pharmacological trials: from lung function to biomarkers

For affiliations, please see the Acknowledgements section.

CORRESPONDENCE: M. Cazzola, Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy. Fax: 39 0672596621. E-mail: mario.cazzola{at}uniroma2.it; mcazzola{at}qubisoft.it

Received: July 31, 2006
Accepted November 20, 2007

The American Thoracic Society/European Respiratory Society jointly created a Task Force on "Outcomes for COPD pharmacological trials: from lung function to biomarkers" to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when evaluating the impact of a pharmacological therapy. Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations.