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Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus

¹ Clinic and Policlinic for Pneumology, ² Dept of Intensive Care Medicine, Inselspital, and ³ Institute of Pathology, Bern University Hospital, Bern, Switzerland.

CORRESPONDENCE: L. P. Nicod, Clinic and Policlinic for Pneumology, Bern University Hospital, CH-3010 Bern, Switzerland. Fax: 41 316329833. E-mail: laurent.nicod{at}insel.ch

Keywords: Antisynthetase syndrome, dermatomyositis, interstitial lung diseases, interstitial pulmonary fibrosis, nonspecific interstitial pneumonia, polymyositis

Received: February 6, 2007
Accepted June 28, 2007

Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified.

An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein.

The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone.

A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants.

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