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Published online before print September 5, 2007, 10.1183/09031936.00083507
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Eur Respir J 2007; 30:1180-1185
Copyright ©ERS Journals Ltd 2007

Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America

A. M. B. Menezes1, P. C. Hallal1, R. Perez-Padilla2, J. R. B. Jardim3, A. Muiño4, M. V. Lopez4, G. Valdivia5, M. Montes de Oca6, C. Talamo6, J. Pertuze5, C. G. Victora1 for the Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) Team

1 Federal University of Pelotas, Pelotas, and, 3 Fedral University of Sao Paulo, Sao Paulo, Brazil. 2 National Institute of Respiratory Diseases, Mexico City, Mexico. 4 University of the Republic, Montevideo, Uruguay. 5 Catholic University of Chile, Santiago, Chile. 6 Central University of Venezuela, Caracas, Venezuela.

CORRESPONDENCE: A. M. B. Menezes, Universidade Federal de Pelotas, Rua Marechal Deodoro 1160, 3° piso - 96020-220 - Pelotas, Brazil. Fax: 55 5332841300. E-mail: anamene{at}terra.com.br

Keywords: Chronic bronchitis, chronic obstructive pulmonary disease, developing countries, smoking, spirometry, tuberculosis

Received: July 5, 2007
Accepted August 14, 2007

The aim of the present study was to evaluate the association between history of tuberculosis and airflow obstruction.

A population-based, multicentre study was carried out and included 5,571 subjects aged ≥40 yrs living in one of five Latin American metropolitan areas: Sao Paulo (Brazil); Montevideo (Uruguay); Mexico City (Mexico); Santiago (Chile); and Caracas (Venezuela). Subjects performed pre- and post-bronchodilator spirometry and were asked whether they had ever been diagnosed with tuberculosis by a physician.

The overall prevalence of airflow obstruction (forced expiratory volume in one second/forced vital capacity post-bronchodilator <0.7) was 30.7% among those with a history of tuberculosis, compared with 13.9% among those without a history. Males with a medical history of tuberculosis were 4.1 times more likely to present airflow obstruction than those without such a diagnosis. This remained unchanged after adjustment for confounding by age, sex, schooling, ethnicity, smoking, exposure to dust and smoke, respiratory morbidity in childhood and current morbidity. Among females, the unadjusted and adjusted odds ratios were 2.3 and 1.7, respectively.

In conclusion, history of tuberculosis is associated with airflow obstruction in Latin American middle-aged and older adults.




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