ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online before print August 22, 2007, 10.1183/09031936.00040607
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eichinger, M.
Right arrow Articles by Kauczor, H-U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eichinger, M.
Right arrow Articles by Kauczor, H-U.
Eur Respir J 2007; 30:972-979
Copyright ©ERS Journals Ltd 2007

Magnetic resonance-compatible-spirometry: principle, technical evaluation and application

M. Eichinger1, M. Puderbach1, H-J. Smith2, R. Tetzlaff1, A. Kopp-Schneider3, M. Bock4, J. Biederer5 and H-U. Kauczor1

Depts of 1 Radiology (E010), 3 Biostatistics (C060), and 4 Medical Physics in Radiology (E020), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 2 Research in Respiratory Diagnostics, Berlin, and 5 University Hospital Schleswig Holstein, Kiel, Germany.

CORRESPONDENCE: M. Eichinger, Dept. of Radiology (E010), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Fax: 49 6221422462. E-mail: m.eichinger{at}dkfz.de

Keywords: Body posture, dynamic magnetic resonance imaging, lung, lung function tests, magnetic resonance-compatible-spirometry, pulmonary mechanics

Received: April 5, 2007
Accepted August 2, 2007

The aim of this study was to assess the feasibility and accuracy of a novel magnetic resonance-compatible (MRc)-spirometer. The influence of body posture, magnetic resonance (MR)-setting and image acquisition on lung function was evaluated. Dynamic MR imaging (dMRI) was compared with simultaneously measured lung function.

The development of the MRc-spirometer was based on a commercial spirometer and evaluated by flow-generator measurements and forced expiratory manoeuvres in 34 healthy nonsmokers (17 females and 17 males, mean age 32.9 yrs). Mean differences between forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated and a sample paired t-test and Bland–Altman plots were generated. A total of 11 subjects underwent different subsequent MRc-spirometric measurements to assess the influence of the components of the MR system on lung function.

The mean (95% confidence interval) difference of FEV1 and FVC between the two systems was 0.004 (-0.04–0.04) L and 0.018 (-0.05–0.09) L, respectively. In the subgroup analysis, an influence of the MR-system on FEV1 was found. FEV1 correlated well with the dMRI measurement of the apico-diaphragmatic distance-change after the first second of forced expiration (r = 0.72).

In conclusion, magnetic resonance-compatible-spirometry is feasible, reliable and safe. The magnetic resonance-setting only has a small influence on simultaneously measured forced expiratory volume in one second. Dynamic magnetic resonance imaging measurements correlate well with simultaneously acquired lung function parameters.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the European Respiratory Society.