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Isolated right ventricular dysfunction in systemic sclerosis: latent pulmonary hypertension?

Depts of ¹ Cardiology, ² Pathophysiology, ³ Internal Medicine, and ⁵ Vascular diseases, Hôpital Erasme, Université Libre de Bruxelles, Belgium. ⁴ Laboratory of Echocardiography, Hospital Louis Pradel, Lyon, France.

CORRESPONDENCE: R. Naeije, Laboratory of Physiology, Erasme Campus, CP 604, Route de Lennik, 808, B-1070 Brussels, Belgium. Fax: 32 25554124. E-mail: rnaeije{at}ulb.ac.be

Keywords: Echocardiography, heart failure, pulmonary hypertension, right ventricle, systemic sclerosis, tissue Doppler imaging

Received: March 4, 2007
Accepted July 24, 2007

Right ventricular function is frequently abnormal in patients with systemic sclerosis, but whether this is related to pulmonary vascular complications of the disease is unclear.

Standard echocardiography with tissue Doppler imaging was performed at rest and during exercise for the study of right ventricular function and pulmonary circulation in 25 consecutive systemic sclerosis patients and in 13 age-matched healthy controls.

When compared with the controls, the patients had no difference in systolic right ventricular pressure gradient, but a decreased pulmonary flow acceleration time, and increased right ventricular free wall thickness and end-diastolic dimensions. At the tricuspid annulus, the E maximal velocity was decreased (8.9±4 versus 11.7±2.3 cm·s^–1) and the isovolumic relaxation time corrected to RR interval was increased (6.5±2.9 versus 4.5±2.5%). The tissue Doppler imaging profile at the mitral annulus was similar in both groups. At exercise, 18 patients had a decreased maximum workload and cardiac output, no change in systolic right ventricular pressure gradient, but an increase in the slope of pulmonary artery pressure/flow relationships.

These results suggest that patients with systemic sclerosis may present with latent pulmonary hypertension as a likely cause of right ventricular diastolic dysfunction, as revealed by stress echocardiography and tissue Doppler imaging.

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				R. Faludi, A. Komocsi, J. Bozo, G. Kumanovics, L. Czirjak, L. Papp, and T. Simor Isolated diastolic dysfunction of right ventricle: stress-induced pulmonary hypertension Eur. Respir. J., February 1, 2008; 31(2): 475 - 476. [Full Text] [PDF]