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Effect of genioglossus contraction on pharyngeal lumen and airflow in sleep apnoea patients

¹ Bnai Zion Medical Center, Technion, Haifa, Israel. ² The Johns Hopkins Sleep Disorders Center, Baltimore, MD, USA.

CORRESPONDENCE: A. Oliven, Dept of Internal Medicine, Bnai Zion Medical Center, 47 Golomb Str., Haifa, Israel. Fax: 972 48359770. E-mail: oliven{at}tx.technion.ac.il

Keywords: Genioglossus, muscle, pharynx, sleep-disordered breathing, upper airway

Received: October 7, 2006
Accepted May 23, 2007

The purpose of the present study was to quantify the mechanical effect of genioglossus stimulation on flow mechanics and pharyngeal cross-sectional area in patients with obstructive sleep apnoea, and to identify variables that determine the magnitude of the respiratory effect of tongue protrusion.

The pressure/flow and pressure/cross-sectional area relationships of the velo- and oropharynx were assessed in spontaneously breathing propofol-anaesthetised subjects before and during genioglossus stimulation.

Genioglossus contraction decreased the critical pressure significantly from 1.2±3.3 to -0.7±3.8 cmH₂O, with individual decreases ranging -0.6–5.9 cmH₂O. Pharyngeal compliance was not affected by genioglossus contraction. The pharyngeal response to genioglossus stimulation was related to the magnitude of advancement of the posterior side of the tongue, but not to the severity of sleep apnoea, critical pressure, compliance or the shape and other characteristics of the velopharynx.

Genioglossus contraction enlarges both the velo- and the oropharynx and lowers the critical pressure without affecting pharyngeal stiffness. The response to genioglossus stimulation depends upon the magnitude of tongue protrusion achieved rather than on inherent characteristics of the patient and their airway.

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				R. F. Fregosi Influence of tongue muscle contraction and dynamic airway pressure on velopharyngeal volume in the rat J Appl Physiol, March 1, 2008; 104(3): 682 - 693. [Abstract] [Full Text] [PDF]