HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Gamble, E. Articles by Barnes, N. C. Search for Related Content PubMed PubMed Citation Articles by Gamble, E. Articles by Barnes, N. C.

Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis

E. Gamble^1,2, D. C. Grootendorst³, K. Hattotuwa¹, T. O'Shaughnessy⁴, F. S. F. Ram⁵, Y. Qiu², J. Zhu², A. M. Vignola, ⁶, C. Kroegel⁷, F. Morell⁸, I. D. Pavord⁹, K. F. Rabe³, P. K. Jeffery² and N. C. Barnes¹

¹ Dept of Respiratory Medicine, The London Chest Hospital, ² Lung Pathology, Imperial College London at the Royal Brompton Hospital, and ⁴ Dept of Respiratory Medicine, Newham University Hospital NHS Trust, London, and ⁹ Dept of Respiratory Medicine, Glenfield Hospital, Leicester, UK. ³ Dept of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands. ⁵ Massey University School of Health Sciences, Auckland, New Zealand. ⁶ Institute of Respiratory Pathophysiology, Palermo, Italy. ⁷ Dept of Pneumology and Allergy, University Medical Clinic, Jena, Germany. ⁸ Pneumology Service, Tres Torres Clinic, Vall d’Hebron Hospital, Barcelona, Spain.

CORRESPONDENCE: N. C. Barnes, Dept of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX, UK. Fax: 44 2089832279. E-mail: neil.barnes{at}bartsandthelondon.nhs.uk

Keywords: Chronic obstructive pulmonary disease, inflammation, smoking, smoking cessation

Received: January 27, 2006
Accepted May 7, 2007

Bronchial biopsy specimens from chronic obstructive pulmonary disease (COPD) patients demonstrate increased numbers of CD8+ T-lymphocytes, macrophages and, in some studies, neutrophils and eosinophils. Smoking cessation affects the rate of forced expiratory volume in one second (FEV₁) decline in COPD, but the effect on inflammation is uncertain. Bronchial biopsy inflammatory cell counts were compared in current and ex-smokers with COPD.

A pooled analysis of subepithelial inflammatory cell count data from three bronchial biopsy studies that included COPD patients who were either current or ex-smokers was performed.

Cell count data from 101 subjects, 65 current smokers and 36 ex-smokers, were analysed for the following cell types: CD4+ and CD8+ T-lymphocytes, CD68+ (monocytes/macrophages), neutrophil elastase+ (neutrophils), EG2+ (eosinophils), mast cell tryptase+ and cells mRNA-positive for tumour necrosis factor-. Current smokers and ex-smokers were similar in terms of lung function, as measured by FEV₁ (% predicted), forced vital capacity (FVC) and FEV₁/FVC. The results demonstrate that there were no significant differences between smokers and ex-smokers in the numbers of any of the inflammatory cell types or markers analysed.

It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke.

This article has been cited by other articles:

				M. Tsoumakidou, I. K. Demedts, G. G. Brusselle, and P. K. Jeffery Dendritic Cells in Chronic Obstructive Pulmonary Disease: New Players in an Old Game Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1180 - 1186. [Abstract] [Full Text] [PDF]

				W. MacNee Update in Chronic Obstructive Pulmonary Disease 2007 Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 820 - 829. [Full Text] [PDF]