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T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease

Dept of Paediatric Pneumology and Immunology, Charité Medical University of Berlin, Berlin, Germany.

CORRESPONDENCE: E. Hamelmann, Dept of Paediatric Pneumology and Immunology, Charite - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. Fax: 49 30450566931. E-mail: eckard.hamelmann{at}charite.de

Keywords: Allergic airway disease, asthma, co-stimulation, T-cells, therapeutic targets

Received: July 18, 2006
Accepted December 29, 2006

The first two articles in this series discussed the fundamental concept of T-cell co-stimulation as a key event in the induction of any immune response, in addition to reviewing the current data on the role of co-stimulatory molecules for the induction and progression of allergic airway diseases. Based on these considerations, this final edition will delineate and discuss novel strategies for the prevention and/or therapy of allergic diseases based upon the modulation of co-stimulation.