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Ionic mechanisms and Ca²⁺ handling in airway smooth muscle

Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph’s Hospital, Dept of Medicine, McMaster University, Hamilton, Ontario, Canada.

CORRESPONDENCE: L. J. Janssen, L-314, St Joseph’s Hospital, 50 Charlton Ave East, Hamilton, Ontario, Canada L8N 4A6. Fax: 1 9055406510. E-mail: janssenl{at}mcmaster.ca

Keywords: Airway physiology, airway smooth muscle, calcium, contraction, ion channels, membrane potential

Received: November 14, 2006
Accepted December 13, 2006

Asthma is a disease characterised by reversible contraction of airway smooth muscle. Many signalling pathways are now known to underlie that contraction, almost all of which revolve around Ca²⁺ handling. Ca²⁺ homeostasis in turn is governed by a wide variety of ionic mechanisms, which are still poorly understood. The present review will briefly summarise those mechanisms that have been recognised for decades, but will then devote considerable attention to several novel ionic signalling mechanisms such as capacitative Ca²⁺ entry, the reverse mode of the Na⁺/Ca²⁺ exchanger, the role of Cl^- channels in the release of internal Ca²⁺ and that of ryanodine receptors in the refilling of the sarcoplasmic reticulum, as well as the regulation of the monomeric G-protein Rho by ionic mechanisms. Lastly, evidence will be provided that Ca²⁺-dependent contraction may be driven by spatial and temporal heterogeneities in the intracellular Ca²⁺ concentration (i.e. Ca²⁺ waves/oscillations) rather than by an increase in the global steady state intracellular Ca²⁺ concentration.

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